U.S.-Chile Cooperative Science Program: Ionic and ReductantFactors Effecting Vesicle Acidification and Iron Mobilization

9224245玻璃美洲奖将支持路易斯安那州立医学中心的乔纳森·格拉斯博士和智利大学的M.T.努内斯·冈萨雷斯就铁摄取的细胞机制的探索进行的合作研究。这项研究的重点是对转铁蛋白转运铁所需事件的生化分析，最终目的是阐明铁的转运机制。智利方面的实验室将重点利用兔网织红细胞，通过离子通量调节囊泡pH来获得铁动员的详细分析，而主要调查者的实验室将根据离子组成和膜电位来确定动员速率。研究结果将有助于更好地了解人类细胞新陈代谢的基本方面。***

9224245 Glass This Americas Award will support collaborative research between Drs. Jonathan Glass, Louisiana State Medical Center, and M. T. Nunez Gonzalez, University of Chile, on the exploration of the cellular mechanism of iron uptake. The focus of this research is on the biochemical analysis of the events required for iron delivery from transferrin, with the ultimate aim of elucidating the mechanism of iron transport. The laboratory on the Chilean side will focus on utilizing rabbit reticulocytes to obtain detailed analyses of iron mobilization via the regulation of vesicular pH by ionic fluxes, while the laboratory of the principal investigator will determine mobilization rates as a function of ionic composition and membrane potential. Results of the research will contribute to a better understanding of the fundamental aspects of human cellular metabolism. ***