VPW: Compartmental Models of Cell Growth (Computational Mathematics)

VPW：细胞生长的区室模型（计算数学）

• 批准号: 9252994
• 负责人: Betty Tang
• 金额: $ 7.98万
• 依托单位: Harvey Mudd College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-01-01 至 1994-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9252994&HistoricalAwards=false
• 关键词: VPW; Compartmental; Models; Cell; Growth

This research is relative to a compartmental model of the cell growth cycle to better understand the triggering mechanism for the initiation of DNA synthesis and mitosis. The model was first proposed and analyzed by Busenberg and Mahffy who showed that the increase in cell size can trigger biochemical oscillations leading to DNA synthesis. The relation between nutrient supply and increase in cell size is, however, now well understood. In addition, the geometrical shape of the cell is an important factor in the triggering mechanism and so far only the case of a spherical cell has been treated. The research will investigate the effect of nutrient supply and the shape of the cell on the initiation of DNA synthesis. The project furthers VPW program objectives to provide opportunities for women to advance their careers in science or engineering through research, and to encourage other women to pursue careers in these areas through the investigator's enhanced visibility as a role model on the host campus. The proposed activities which contribute to the second objective include: teaching two sections of an elementary differential equations course, which will enable the P.I. to interact with many students in their freshman or sophomore years; organizing, jointly with Busenberg, a weekly Mathematical Biology Seminar; giving a series of lectures on her own research; and inviting applied mathematicians from other universities as guest speakers, six of whom would be women; providing guidance and counseling, especially to women students.

这项研究是相对于房室模型的 细胞生长周期，以更好地了解触发机制 启动DNA合成和有丝分裂。 该模型 布森伯格和马赫菲首先提出并分析了这个问题， 显示细胞大小的增加可以触发生物化学反应， 振荡导致DNA合成。 的关系 然而，营养供应和细胞大小的增加现在很好 明白 此外，细胞的几何形状是 触发机制中的重要因素，迄今为止， 一个球形细胞的情况下已经处理。 这项研究将调查营养供应的影响 以及细胞的形状对DNA合成的影响。 该项目进一步推动了VPW计划的目标， 妇女在科学领域发展事业的机会， 通过研究工程，并鼓励其他妇女， 追求职业生涯在这些领域通过调查员的增强 作为东道校园的榜样。 拟议 有助于实现第二个目标的活动包括： 一个初等微分方程的两节教学 这将使P.I.与许多学生互动， 他们的大一或大二;组织，共同与 布森伯格，每周一次的数学生物学研讨会;给出一个 关于她自己研究的一系列讲座;并邀请应用 来自其他大学的数学家作为嘉宾讲者， 女性，是一个引导和引导的人。 尤其是对女学生。