Heavy Metal Accumulation and Toxicity in Urban and Remote Chihuahuan Desert

城市和偏远奇瓦瓦沙漠的重金属积累和毒性

• 批准号: 9253021
• 负责人: William MacKay
• 金额: $ 35万
• 依托单位: University of Texas at El Paso
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-15 至 1996-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9253021&HistoricalAwards=false
• 关键词: Heavy; Metal; Accumulation; Toxicity; Urban

A primary goal of the proposed research is to investigate an environment that historically has been subject to contamination by heavy metals, and to examine the putative toxicological effects of these heavy metals (particularly arsenic and lead) on samples of the biota characteristic of the heavily urbanized and industrialized El Paso/Cd. Juarez region in the northern Chihuahuan Desert. Using both the urbanized region and a study area remote from the urban area as a control habitat, studies, using multidisciplinary, integrated approach will be undertaken to (1) assess the extent of heavy metal contamination in representative species and the distribution of the contaminants through the food web, (2) analyze the capacity of microbes to metabolize the heavy metal contaminants and adjust for them at the molecular genetic level and (3) investigate the putative mechanisms of toxicity at the cellular level through experiments, initially, on plant growth, mutagenic load and gametogenesis in microfauna. A second goal of the proposed research is to provide a stimulating research/mentoring environment that will promote the entry of underrepresented minorities and women into biological sciences, particularly the rapidly to evolving field of environmental toxicology. Students will have the opportunity to become involved in innovative research from the ground up, by sharing in the responsibility of designing experimental protocols, collecting and analyzing the data. Students involved in the program will be encouraged to present the fruits of their research at local and national meetings, providing them with the opportunity to network with others in the field.

拟议研究的主要目标是调查 历史上一直受到污染的环境， 重金属，并检查推定的毒理学影响， 这些重金属（特别是砷和铅）的样本， 高度城市化和工业化的El的生物群特征 帕索河位于奇瓦瓦沙漠北方的华雷斯地区。 使用 城市化地区和远离城市的研究地区 区域作为控制栖息地，研究，使用多学科，综合 方法将采取（1）评估重金属的程度 代表性物种的污染和 污染物通过食物网，（2）分析的能力， 微生物代谢重金属污染物， 在分子遗传学水平上研究它们;（3）研究假定的 通过实验在细胞水平上的毒性机制， 最初，在植物生长、诱变负荷和配子发生中， 微型动物群 拟议研究的第二个目标是提供一个激励 研究/指导环境，将促进进入 代表性不足的少数民族和妇女进入生物科学， 特别是快速发展的环境毒理学领域。 学生将有机会参与创新 研究从地上爬起来，通过分担责任， 设计实验方案，收集和分析数据。 参与该计划的学生将被鼓励提出 他们的研究成果在地方和国家会议，提供他们 有机会与该领域的其他人建立联系。