NSF Young Investigator/Control of Protein Secondary Structures

NSF 青年研究员/蛋白质二级结构控制

• 批准号: 9258320
• 负责人: James Nowick
• 金额: $ 31.25万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-01 至 1996-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9258320&HistoricalAwards=false
• 关键词: NSF; Young; Investigator; Control; Protein

This grant from the Organic Dynamics Program supports the work of Professor James S. Nowick at the University of California Irvine. A new strategy will be developed for controlling peptide secondary structure by linking multiple amino acid chains to a stiff oligomeric backbone that serves as a molecular scaffold. The molecular scaffold will be based upon an oligourea that will be synthesized in an iterative fashion. This strategy will be used to create beta-sheets and to develop molecular receptors for small peptides. %%% The three dimensional structure of a peptide will be controlled by linking the peptide chain to a rigid molecular backbone. The backbone will be designed to hold several peptides in parallel and antiparallel fashions. This represents a fundamentally new approach to the control of protein structure. The design of the backbone is ideally suited for the development of receptors for small peptides.

这项来自有机动力学项目的资助支持了这项工作 詹姆斯·S教授加州大学的Nowick 欧文 将制定新的控制策略 多氨基酸连接肽二级结构 链连接到刚性低聚骨架上， 分子支架 分子支架将基于 将以迭代方式合成的寡核苷酸。 这一策略将用于创建β-片层并开发 小肽的分子受体。 %%% 肽的三维结构将被控制， 通过将肽链连接到刚性分子骨架上。 骨架将被设计成容纳几个肽， 平行和反平行的方式。 这表示 这是控制蛋白质结构的全新方法。 骨干网的设计非常适合 小肽受体的发育。