NSF Young Investigator/Control of Protein Secondary Structures

这项来自有机动力学项目的资助支持了这项工作 詹姆斯·S教授加州大学的Nowick 欧文 将制定新的控制策略 多氨基酸连接肽二级结构 链连接到刚性低聚骨架上， 分子支架。 分子支架将基于 将以迭代方式合成的寡核苷酸。 这一策略将用于创建β-片层并开发 小肽的分子受体。 %%% 肽的三维结构将被控制， 通过将肽链连接到刚性分子骨架上。 骨架将被设计成容纳几个肽， 平行和反平行的方式。 这表示 这是控制蛋白质结构的全新方法。 骨干网的设计非常适合 小肽受体的发育。

This grant from the Organic Dynamics Program supports the work of Professor James S. Nowick at the University of California Irvine. A new strategy will be developed for controlling peptide secondary structure by linking multiple amino acid chains to a stiff oligomeric backbone that serves as a molecular scaffold. The molecular scaffold will be based upon an oligourea that will be synthesized in an iterative fashion. This strategy will be used to create beta-sheets and to develop molecular receptors for small peptides. %%% The three dimensional structure of a peptide will be controlled by linking the peptide chain to a rigid molecular backbone. The backbone will be designed to hold several peptides in parallel and antiparallel fashions. This represents a fundamentally new approach to the control of protein structure. The design of the backbone is ideally suited for the development of receptors for small peptides.