Presidential Faculty Fellows Program

总统教员研究员计划

• 批准号: 9553262
• 负责人: James Nowick
• 金额: $ 20万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-01 至 1998-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9553262&HistoricalAwards=false
• 关键词: Presidential; Faculty; Fellows; Program

With funding from this Presidential Faculty Fellow award, Professor Nowick will elaborate the factors affecting the structure and interactions of biologically relevant molecules. For example, the aim of this work is to develop new strategies for the delivery of biologically active nucleic acid derivatives across cell membranes and to gain fundamental insight into protein structure. This is accomplished by modifying a micelle with a receptor molecule such as a nucleic acid component thymine. Subsequent, introduction of a complimentary drug which hydrogen bonds with the base provides a means for transporting a rather polar compound across lipid bilayers or biological membranes. By exploring inhibitors and a variety of other molecular probes it will be possible to gather information on 3 dimensional peptide structure and how it effects molecular transport. In specific, this research addresses the subject of protein folding which is a problem on many investigator's palettes. Understanding the principles by which physiologically active compounds are bound and transported across cell membranes would provide scientists with tools for making new drugs, making those presently known more effective and creating new artificial systems which are medically beneficial to mankind. This awardee and this project are destined to have a major impact on this subject area and thereby is highly significant.

在总统教职研究员奖的资助下，诺维克教授将详细阐述影响生物学相关分子的结构和相互作用的因素。例如，这项工作的目的是开发跨细胞膜递送生物活性核酸衍生物的新策略，并获得对蛋白质结构的基本了解。这是通过用受体分子（例如核酸成分胸腺嘧啶）修饰胶束来实现的。随后，引入与碱基形成氢键的互补药物，提供了一种跨脂质双层或生物膜运输极性较大的化合物的方法。通过探索抑制剂和各种其他分子探针，将有可能收集有关 3 维肽结构及其如何影响分子转运的信息。具体来说，这项研究解决了蛋白质折叠的问题，这是许多研究人员面临的一个问题。 了解生理活性化合物在细胞膜上结合和运输的原理将为科学家提供制造新药的工具，使目前已知的药物更加有效，并创建对人类医学有益的新人工系统。该获奖者和该项目注定会对该学科领域产生重大影响，因此意义重大。