Presidential Faculty Fellows Program

在总统学院院士奖的资助下，诺维克教授将详细阐述影响生物相关分子的结构和相互作用的因素。例如，这项工作的目的是开发新的策略，通过细胞膜输送具有生物活性的核酸衍生物，并获得对蛋白质结构的基本见解。这是通过用受体分子如核酸成分胸腺嘧啶修饰胶束来实现的。随后，引入了一种与碱基氢键结合的补充药物，提供了一种通过脂质双层或生物膜传输相当极性的化合物的方法。通过探索抑制剂和各种其他分子探针，将有可能收集关于三维多肽结构及其如何影响分子运输的信息。具体地说，这项研究解决了蛋白质折叠的问题，这是许多研究人员调色板上的一个问题。了解生理活性化合物结合和跨细胞膜运输的原理将为科学家提供制造新药的工具，使目前已知的药物更有效，并创造对人类有益的新的人工系统。这位获奖者和这个项目注定会对这一主题领域产生重大影响，因此具有非常重要的意义。

With funding from this Presidential Faculty Fellow award, Professor Nowick will elaborate the factors affecting the structure and interactions of biologically relevant molecules. For example, the aim of this work is to develop new strategies for the delivery of biologically active nucleic acid derivatives across cell membranes and to gain fundamental insight into protein structure. This is accomplished by modifying a micelle with a receptor molecule such as a nucleic acid component thymine. Subsequent, introduction of a complimentary drug which hydrogen bonds with the base provides a means for transporting a rather polar compound across lipid bilayers or biological membranes. By exploring inhibitors and a variety of other molecular probes it will be possible to gather information on 3 dimensional peptide structure and how it effects molecular transport. In specific, this research addresses the subject of protein folding which is a problem on many investigator's palettes. Understanding the principles by which physiologically active compounds are bound and transported across cell membranes would provide scientists with tools for making new drugs, making those presently known more effective and creating new artificial systems which are medically beneficial to mankind. This awardee and this project are destined to have a major impact on this subject area and thereby is highly significant.