Presidential Faculty Fellows Program

诺威克教授将利用该奖项的资助，详细阐述影响生物相关分子结构和相互作用的因素。例如，这项工作的目的是开发跨细胞膜传递生物活性核酸衍生物的新策略，并获得对蛋白质结构的基本见解。这是通过修饰胶束与受体分子，如核酸成分胸腺嘧啶。随后，引入氢键与碱结合的补充药物，提供了一种通过脂质双分子层或生物膜运输极性化合物的方法。通过探索抑制剂和各种其他分子探针，将有可能收集有关三维肽结构及其如何影响分子运输的信息。具体地说，这项研究解决了蛋白质折叠的问题，这是许多研究者的调色板上的一个问题。了解生理活性化合物结合和跨细胞膜运输的原理，将为科学家提供制造新药的工具，使目前已知的药物更有效，并创造新的人工系统，对人类医学有益。这个获奖者和这个项目注定会对这个主题领域产生重大影响，因此非常重要。

With funding from this Presidential Faculty Fellow award, Professor Nowick will elaborate the factors affecting the structure and interactions of biologically relevant molecules. For example, the aim of this work is to develop new strategies for the delivery of biologically active nucleic acid derivatives across cell membranes and to gain fundamental insight into protein structure. This is accomplished by modifying a micelle with a receptor molecule such as a nucleic acid component thymine. Subsequent, introduction of a complimentary drug which hydrogen bonds with the base provides a means for transporting a rather polar compound across lipid bilayers or biological membranes. By exploring inhibitors and a variety of other molecular probes it will be possible to gather information on 3 dimensional peptide structure and how it effects molecular transport. In specific, this research addresses the subject of protein folding which is a problem on many investigator's palettes. Understanding the principles by which physiologically active compounds are bound and transported across cell membranes would provide scientists with tools for making new drugs, making those presently known more effective and creating new artificial systems which are medically beneficial to mankind. This awardee and this project are destined to have a major impact on this subject area and thereby is highly significant.