Presidential Faculty Fellows Program

在总统学院研究员奖的资助下，教授 Nowick将详细阐述影响结构的因素， 生物相关分子的相互作用。例如， 这项工作是开发新的战略， 活性核酸衍生物穿过细胞膜， 对蛋白质结构的基本认识。这是通过 用受体分子如核酸修饰胶束 成分胸腺嘧啶。随后，推出了一种免费药物， 与碱的氢键提供了一种运输相当多的 极性化合物穿过脂质双层或生物膜。通过 探索抑制剂和各种其他分子探针， 可以收集关于三维肽结构的信息， 它影响分子运输。具体来说，这项研究解决了 蛋白质折叠是许多研究者 调色板 了解生理活性化合物 结合并通过细胞膜运输， 制造新药的工具， 创造新的人工系统， 对人类有益。这个获奖者和这个项目注定要有 对这一主题领域产生重大影响，因此意义重大。

With funding from this Presidential Faculty Fellow award, Professor Nowick will elaborate the factors affecting the structure and interactions of biologically relevant molecules. For example, the aim of this work is to develop new strategies for the delivery of biologically active nucleic acid derivatives across cell membranes and to gain fundamental insight into protein structure. This is accomplished by modifying a micelle with a receptor molecule such as a nucleic acid component thymine. Subsequent, introduction of a complimentary drug which hydrogen bonds with the base provides a means for transporting a rather polar compound across lipid bilayers or biological membranes. By exploring inhibitors and a variety of other molecular probes it will be possible to gather information on 3 dimensional peptide structure and how it effects molecular transport. In specific, this research addresses the subject of protein folding which is a problem on many investigator's palettes. Understanding the principles by which physiologically active compounds are bound and transported across cell membranes would provide scientists with tools for making new drugs, making those presently known more effective and creating new artificial systems which are medically beneficial to mankind. This awardee and this project are destined to have a major impact on this subject area and thereby is highly significant.