MRI: Acquisition of a Cryoprobe for a 600 MHz NMR Spectrometer

在重大研究仪器计划(MRI)的这一奖项和化学研究仪器计划(CRIF)的支持下，加州大学欧文分校的James Nowick教授及其同事Vy Dong和Christopher Vanderwal将获得一个将安装在600 MHz核磁共振光谱仪上的低温探测器(宽带和氟观测，BBFO)。这种附件将大大提高光谱仪的灵敏度，而成本只是新光谱仪的一小部分，并将允许在各种领域进行研究，例如那些加速具有重大经济意义的化学反应的领域，以及对生物相关物种的研究。总的来说，核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将是加州大学欧文分校博士后、研究生和本科生教学和研究的组成部分，还将影响涉及K-12项目的外展活动，这些项目以少数民族为主的学校为目标。该奖项旨在加强各级的研究和教育，特别是在以下领域：(A)开发机制和金属催化的方法；(B)催化氢酰化；(C)设计捕获一氧化碳的分子和材料；(D)合成连接的氮杂菲；(E)开发立体选择性形成季碳立体中心和碎片偶联的新方法；(F)合成巴曲霉毒素及其类似物；和(G)复杂生物活性天然产物的化学合成。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor James Nowick from the University of California Irvine and colleagues Vy Dong and Christopher Vanderwal will acquire a cryoprobe (broad band and fluorine observe, BBFO) that will be installed on a 600 MHz NMR spectrometer. This attachment will greatly increase the sensitivity of the spectrometer at a fraction of the cost of new spectrometer and will allow research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as the study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research by postdoctoral, graduate and undergraduate students at the University of California at Irvine and will also impact outreach activities involving K-12 programs that target schools with predominantly minority populations.The award is aimed at enhancing research and education at all levels, especially in areas such as (a) developing mechanisms and metal-catalyzed methods; (b) catalytic hydroacylation; (c) designing molecules and materials that capture carbon monoxide; (d) synthesizing linked aza-phenanthrenes; (e) developing new approaches for stereoselective formation of quaternary carbon stereocenters and fragment coupling; (f) synthesizing batrachotoxin and its analogues; and (g) chemical synthesis of complex bioactive natural products.