MRI: Acquisition of a Cryoprobe for a 600 MHz NMR Spectrometer

在主要研究仪器计划（MRI）的这一奖项和化学研究仪器计划（CRIF）的支持下，来自加州欧文大学的James Nowick教授及其同事Vy Dong和Christopher Vanderwal将获得一个冷冻探针（宽带和氟观察，BBFO），该探针将安装在600 MHz NMR光谱仪上。这种附件将大大提高光谱仪的灵敏度，而成本只是新光谱仪的一小部分，并将允许在各种领域进行研究，例如那些加速具有重大经济意义的化学反应的领域，以及生物学相关物种的研究。一般来说，核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。这一工具将成为加州大学欧文分校博士后、研究生和本科生教学和研究的一个组成部分，还将影响涉及K-12计划的外联活动，这些计划针对的是少数民族占主导地位的学校。（B）催化加氢酰化;（c）设计捕获一氧化碳的分子和材料;（d）合成连接的氮杂菲;（e）开发立体选择性形成季碳立体中心和片段偶联的新方法;（f）合成蛙毒素及其类似物;和（g）化学合成复杂的生物活性天然产物。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor James Nowick from the University of California Irvine and colleagues Vy Dong and Christopher Vanderwal will acquire a cryoprobe (broad band and fluorine observe, BBFO) that will be installed on a 600 MHz NMR spectrometer. This attachment will greatly increase the sensitivity of the spectrometer at a fraction of the cost of new spectrometer and will allow research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as the study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research by postdoctoral, graduate and undergraduate students at the University of California at Irvine and will also impact outreach activities involving K-12 programs that target schools with predominantly minority populations.The award is aimed at enhancing research and education at all levels, especially in areas such as (a) developing mechanisms and metal-catalyzed methods; (b) catalytic hydroacylation; (c) designing molecules and materials that capture carbon monoxide; (d) synthesizing linked aza-phenanthrenes; (e) developing new approaches for stereoselective formation of quaternary carbon stereocenters and fragment coupling; (f) synthesizing batrachotoxin and its analogues; and (g) chemical synthesis of complex bioactive natural products.