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A unified approach to determine how MUS81-EME1 recognizes and cleaves branched DNA structures to safeguard genome integrity

A unified approach to determine how MUS81-EME1 recognizes and cleaves branched DNA structures to safeguard genome integrity
确定 MUS81-EME1 如何识别和切割分支 DNA 结构以保护基因组完整性的统一方法
批准号:
469076
负责人:
Wyatt Haley D
金额:
$72.45万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2022
资助国家:
加拿大
项目状态:
未结题
起止时间:
2022-09-01 至 2027-09-01

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中文摘要
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英文摘要
Cancer is a leading cause of death worldwide. One hallmark of cancer cells is a high frequency of mutations and DNA rearrangements, collectively known as genome instability. Persistent DNA damage fuels genome instability and paradoxically, genomes are con
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会议论文
6th Canadian Symposium on Telomeres and Genome Integrity
  • 批准号:
    480746
  • 项目类别:
    Miscellaneous Programs
  • 资助金额:
    $0.73万
  • 财政年份:
    2023
  • 负责人:
    Wyatt Haley D
  • 依托单位:
Prize 202209PJT - Early Career Award in Cancer: A unified approach to determine how MUS81-EME1 recognizes and cleaves branched DNA structures to safeguard genome integrity
  • 批准号:
    477687
  • 项目类别:
    Operating Grants
  • 资助金额:
    $1.82万
  • 财政年份:
    2022
  • 负责人:
    Wyatt Haley D
  • 依托单位:
Canada Research Chair - Tier 2
  • 批准号:
    459706
  • 项目类别:
  • 资助金额:
    $36.43万
  • 财政年份:
    2021
  • 负责人:
    Wyatt Haley D
  • 依托单位:
Mechanistic studies of the SMX tri-nuclease with direct links to genome stability
  • 批准号:
    368638
  • 项目类别:
    Operating Grants
  • 资助金额:
    $68.83万
  • 财政年份:
    2017
  • 负责人:
    Wyatt Haley D
  • 依托单位:
国内基金
海外基金
中国北方人群肺癌患者Cancer/Testis抗原表达谱绘制表位鉴定及功能性抗原特异性CTL制备研究
  • 批准号:
    81673007
  • 项目类别:
    面上项目
  • 资助金额:
    54.0万元
  • 批准年份:
    2016
  • 负责人:
    金时
  • 依托单位: