A unified approach to determine how MUS81-EME1 recognizes and cleaves branched DNA structures to safeguard genome integrity
确定 MUS81-EME1 如何识别和切割分支 DNA 结构以保护基因组完整性的统一方法
基本信息
- 批准号:469076
- 负责人:
- 金额:$ 72.45万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Operating Grants
- 财政年份:2022
- 资助国家:加拿大
- 起止时间:2022-09-01 至 2027-09-01
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Cancer is a leading cause of death worldwide. One hallmark of cancer cells is a high frequency of mutations and DNA rearrangements, collectively known as genome instability. Persistent DNA damage fuels genome instability and paradoxically, genomes are con
癌症是世界范围内的主要死亡原因。癌细胞的一个标志是高频率的突变和DNA重排,统称为基因组不稳定性。持续的DNA损伤加剧了基因组的不稳定性,矛盾的是,基因组是不稳定的。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Wyatt Haley D其他文献
Wyatt Haley D的其他文献
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{{ truncateString('Wyatt Haley D', 18)}}的其他基金
6th Canadian Symposium on Telomeres and Genome Integrity
第六届加拿大端粒和基因组完整性研讨会
- 批准号:480746 
- 财政年份:2023
- 资助金额:$ 72.45万 
- 项目类别:Miscellaneous Programs 
Prize 202209PJT - Early Career Award in Cancer: A unified approach to determine how MUS81-EME1 recognizes and cleaves branched DNA structures to safeguard genome integrity
奖 202209PJT - 癌症早期职业奖:确定 MUS81-EME1 如何识别和切割分支 DNA 结构以保护基因组完整性的统一方法
- 批准号:477687 
- 财政年份:2022
- 资助金额:$ 72.45万 
- 项目类别:Operating Grants 
Mechanistic studies of the SMX tri-nuclease with direct links to genome stability
与基因组稳定性直接相关的 SMX 三核酸酶的机制研究
- 批准号:368638 
- 财政年份:2017
- 资助金额:$ 72.45万 
- 项目类别:Operating Grants 
相似国自然基金
中国北方人群肺癌患者Cancer/Testis抗原表达谱绘制表位鉴定及功能性抗原特异性CTL制备研究
- 批准号:81673007
- 批准年份:2016
- 资助金额:54.0 万元
- 项目类别:面上项目
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