Purchase of a Gas Chromatograph with Mass Spectral Detector

化学研究仪器计划的这个奖项 将协助大学化学系 在内布拉斯加州购买了一台气相色谱仪， 光谱检测器（GC-MS）。 这个最先进的长凳 GC-MS对于满足当前和未来的研究需求至关重要， 化学系，主要是在合成组， 本部门 该仪器对于以下研究至关重要： 该部门包括以下领域： 1)新的催化过渡金属介导的碳环化， 2)新型治疗剂的生物有机方法， （磷酸盐抑制剂，氨基酸脱羧酶抑制剂，和 （-）-鬼臼毒素的化学酶法），3）新的 使用高活性金属的合成方法， 4)氢过氧化物的生物有机与合成化学 （1，4-二烯的立体选择性双氧化和合成 氢过氧化物）， 5)分子内铁磁耦合 三氮氧化物， 6)理论与实验物理有机化学 （硅氧烷研究和硝基和亚硝基加成）。 %%% 带质谱检测器的气相色谱仪（GC-MS） 允许人们分离化合物的混合物， 每种化合物的分子量。 这 信息是一种重要的信息 为了确定分子式和/或分子量， 新合成化合物的分子结构。

This award from the Chemistry Research Instrumentation Program will assist the Department of Chemistry at the University of Nebraska in the purchase of a gas chromatograph with a mass spectral detector (GC-MS). This state-of-the-art bench top GC-MS is essential to meet current and future research needs of the Chemistry Department, primarily in the synethic groups in the Department. This instrument is essential for research in the department which includes the following areas: 1) New catalytic transition metal mediated carbocyclizations, 2) Bioorganic approaches to novel therapeutic agents, (phosphate inhibitors, amino acid decarboxylase inhibitors, and a chemoenzymatic approach to the (-)-podophyllotoxin),3) New synthetic methods using highly active metals, 4) Bioorganic and synthetic chemistry of hydroperoxides (steroselective dioxygenation of 1,4 dienes and synthesis of hydroperoxides), 5) Intramolecular ferromagnetic coupling in di- and trinitroxides, 6) Theoretical and experimental physical organic chemistry (siloxane research and nitro and nitroso additions). %%% The gas chromatograph with the mass spectral detector (GC-MS) allows one to separate a mixture of compounds and to measure the molecule weight of each of the individual compounds. This information is one of the essential pieces of information needed in order to determine the molecular formula and/or the molecular structure of newly synthesized compounds.