Assessing functional impacts of disease-associated mutations in G-protein “other”

评估 G 蛋白 - 其他 - 疾病相关突变的功能影响

• 批准号: 486559
• 负责人: Alonzi Nicholas A
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-12-01 至 2023-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=486559&lang=en
• 关键词: Developmental Disorder; Functional Assay; G-Protein; G-Protein Coupled Receptor; Gtpase Activity; Movement Disorder; Neuropathology; Nuclear Magnetic Resonance; Rescue Of Function; Small-Molecule Fluorescence

G-proteins are GTPases that hydrolyze GTP, conduct intracellular signals across various cells, and maintain homeostasis upon activation. Regulators of G-proteins are divided into guanine nucleotide exchange factors (GEFs) which promote G-protein activatio

G蛋白是水解GTP、跨各种细胞传导细胞内信号并在激活后维持稳态的GTP酶。G蛋白的调节因子分为促进G蛋白活化的鸟嘌呤核苷酸交换因子（GEFs）和促进G蛋白活化的鸟嘌呤核苷酸交换因子（GEFs）。