An investigation into sex dimorphic effects on mitochondrial protein S-glutathionylation reactions in the liver of mice fed a high fat diet

性别二态性对高脂饮食小鼠肝脏线粒体蛋白 S-谷胱甘肽化反应影响的研究

• 批准号: 486332
• 负责人: Grayson Cathryn
• 金额: $ 1.27万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-12-01 至 2023-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=486332&lang=en
• 关键词: Bioenergetics; Fat Metabolism; Fatty Liver Disease; Glutaredoxin; Glutathionylation; Mitochondria; Obesity; Redox Signalling; Ros Homeostasis; Sex Dimorphisms

Obesity is a global health epidemic, affecting 26.8% of the Canadian adult population. Development of co-morbidities such as non-alcoholic fatty liver disease (NAFLD) increase obesity-related mortality. Mitochondria are the powerhouses of mammalian cells

肥胖是一种全球性的健康流行病，影响了26.8%的加拿大成年人。非酒精性脂肪性肝病（NAFLD）等合并症的发展增加了肥胖相关的死亡率。线粒体是哺乳动物细胞的能量来源