Regulation of Streptomyces antibiotics by mia and abs

mia 和abs 对链霉菌抗生素的调节

• 批准号: 9306676
• 负责人: Wendy Champness
• 金额: $ 5万
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-01 至 1995-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9306676&HistoricalAwards=false
• 关键词: Regulation; Streptomyces; antibiotics; mia; abs

This career advancement award provides partial support for Dr. Champness during a sabbatical leave at the John Innes Institute in Norwich, United Kingdom. Streptomycetes are well-known for their capacity to synthesize a vast repertoire of secondary metabolites (antibiotics). Besides their commercial importance, the Streptomyces are interesting for their complex developmental cycle. In the course of this life cycle, antibiotic synthesis is developmentally regulated. The objective of the research in this proposal is to define aspects of the global genetic regulation of Streptomyces coelicolor antibiotic synthesis. The research planned is based on a set of genes, recently discovered in Dr. Champness laboratory, which regulate the expression of antibiotic genes. The major goal is investigation of the mechanism by which these genes globally regulate antibiotic synthesis. %%% This molecular analysis promises to contribute not only to our understanding of microbial developmental gene regulation, but also to biotechnology. Understanding of S. coelicolor regulation is highly likely to explain much of antibiotic regulation in other Streptomycetes and Actinomycetes, and thus increase the potential for rational manipulation of production of commercially important metabolites including the many new metabolites that are continuously being discovered.

这项职业发展奖为博士提供了部分支持。 在约翰·英尼斯研究所休假期间， 联合王国诺里奇 链霉菌以其 合成大量次级代谢产物的能力 （抗生素）。 除了商业价值， 链霉菌因其复杂的发育周期而令人感兴趣。 在这个生命周期中，抗生素的合成是 发展规律。 这项研究的目的是 建议是确定全球遗传调控的各个方面， 天蓝色链霉菌抗生素合成。 研究计划 是基于一组基因，最近在Chambery博士身上发现的 实验室，它调节抗生素基因的表达。 的 主要目标是研究这些基因 在全球范围内调节抗生素合成。 %%% 这种分子分析不仅有助于我们 了解微生物发育基因调控，而且 到生物技术。 理解S。腔肠调控是 这很可能解释了其他国家对抗生素管制 链霉菌和放线菌，从而增加了潜在的 合理控制商业上重要的 包括许多新的代谢物， 不断被发现。