Synthesis of Indigo and Adipic Acid: Eliminating Fossil Fuels, Toxins and Elevated Reaction Temperatures with Biocatalysis

靛蓝和己二酸的合成：通过生物催化消除化石燃料、毒素和升高的反应温度

• 批准号: 9307107
• 负责人: John Frost
• 金额: $ 20.59万
• 依托单位: Purdue Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 1996-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9307107&HistoricalAwards=false
• 关键词: Synthesis; Indigo; Adipic; Acid; Eliminating

9307107 Frost The focus of this research will be the synthesis of indigo and adipic acid using Escerichia coli as catalysts and D-glucose as starting material. The steps proposed for the biocatalytic syntheses are carried out in water at temperatures not to exceed 37 degrees Centigrade. No greenhouse or ozone-depleting gases will be generated in contrast to currently used methodology. %%% With this Environmentally Benign Chemical Synthesis and Processing award, the Synthetic Organic Program is supporting the research of Dr. John W. Frost of the Department of Chemistry at Purdue University. Professor Frost will focus his work on the synthesis of indigo and adipic acid by using biocatalysts to eliminate materials derived from fossil fuels, toxins and elevated reaction temperatures from the synthetic scheme. ***

9307107 Frost本研究的重点将是使用大肠杆菌作为催化剂和D-葡萄糖作为起始原料合成靛蓝和己二酸。 提出的生物催化合成步骤在不超过37摄氏度的温度下在水中进行。 与目前使用的方法相比，将不会产生温室气体或臭氧消耗气体。 有了这个环境友好的化学合成和加工奖，合成有机计划是支持博士的研究。普渡大学化学系的弗罗斯特。 弗罗斯特教授的工作重点是通过使用生物催化剂合成靛蓝和己二酸，以从合成方案中消除源自化石燃料、毒素和升高反应温度的材料。 ***