Sustainable Synthesis of BTX-Derived Chemicals

BTX 衍生化学品的可持续合成

• 批准号: 1213299
• 负责人: John Frost
• 金额: $ 44.45万
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1213299&HistoricalAwards=false
• 关键词: Sustainable; Synthesis; BTX; Derived; Chemicals

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor John W. Frost of the Department of Chemistry at Michigan State University will interface microbial catalysis with chemical catalysis to convert renewable, nontoxic sugar starting materials into chemicals currently derived from the benzene-toluene-xylene (BTX) stream of petroleum and gas refining. Dienes will be microbe synthesized and chemically reacted with dienophiles to yield cycloaddition products designed to provide access to a new generation of monomers and plasticizers where all carbon atoms are derived from renewable sugars. Catalytic dehydrogenation of the cycloaddition products is to afford substituted terephthalates. Other cycloaddition products will provide access to substituted cyclohexene tricarboxylates and cyclohexane tricarboxylates. Substituted terephthalic acids can impart unique properties when employed as additives or monomers in liquid crystalline polymers used in electronic and medical applications as well as in polyethyleneterephthalate used in clothing fiber and bottle resin. The novel properties that substituted terephthalates impart to engineering and consumer polymers could open new applications and new markets thereby providing an important economic multiplier along with job creation. Similarly, the wide array of ring-substituted cyclohexene and cyclohexane tricarboxylates are targeted towards nonaromatic plasticizer markets. By interfacing microbial synthesis with chemical synthesis, a level of structural diversity is accessed that may ultimately enable the identification of new high-performance plasticizers that do not bind to estrogen receptors. The attendant health safety and environmental benefits would be considerable. Finally, this research program will provide a unique training opportunity for pre-undergraduate, undergraduate, graduate and post-doctoral students, including those from groups historically underrepresented in the sciences.

本研究由化学系化学合成计划资助，由美国加州大学洛杉矶分校的John W.密歇根州立大学化学系的弗罗斯特将微生物催化与化学催化相结合，将可再生的无毒糖原料转化为目前来自石油和天然气精炼的苯-甲苯-二甲苯（BTX）流的化学品。 二烯将通过微生物合成，并与亲二烯体发生化学反应，产生环加成产物，旨在提供新一代单体和增塑剂，其中所有碳原子均来自可再生糖。 环加成产物的催化脱氢得到取代的辛酸酯。 其它环加成产物将提供获得取代的环己烯三羧酸酯和环己烷三羧酸酯的途径。 取代的对苯二甲酸在用作电子和医疗应用中使用的液晶聚合物以及用于服装纤维和瓶子树脂中的聚对苯二甲酸乙二醇酯中的添加剂或单体时可以赋予独特的性能。 取代的丙烯酸酯赋予工程和消费聚合物的新性能可以打开新的应用和新市场，从而提供重要的经济乘数沿着就业机会的创造。 类似地，广泛的环取代的环己烯和环己烷三羧酸酯的目标是非芳族增塑剂市场。 通过将微生物合成与化学合成相结合，可以获得一定程度的结构多样性，最终可以鉴定出不与雌激素受体结合的新型高性能增塑剂。 随之而来的健康、安全和环境效益将是巨大的。 最后，这项研究计划将为本科前，本科，研究生和博士后学生提供一个独特的培训机会，包括那些历史上在科学领域代表性不足的群体。