Synthesis and Equilibrium Studies of 13C-Leupeptin and Derivatives

13C-亮肽素及其衍生物的合成与平衡研究

• 批准号: 9308178
• 负责人: Rose McConnell
• 金额: $ 9万
• 依托单位: University of Arkansas
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-06-01 至 1997-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9308178&HistoricalAwards=false
• 关键词: Synthesis; Equilibrium; Studies; 13C; Leupeptin

The focus of this research is the synthesis of labeled leupeptin derivatives containing 1-13C-argininal. Enzyme activity as proteinase inhibitors will be probed by 13-C-NMR to identify the structures in solution that can possibly act as transition-state analogs. %%% With this Standard Grant RUI award, the Synthethic Organic Program is supporting the research of Dr. Rose M. McConnell of the Department of Natural Sciences at the University of Arkansas, Monticello. Professor McConnell will focus her research of the preparation of 13C-labeled leupeptin derivatives that will be studied by NMR to determine the role of the compounds as proteinase inhibitors. The research is especially ammenable to the involvement of undergraduates.

本研究的重点是合成标记的 含有1- 13 C-亮氨酸的亮肽素衍生物。 酶 将通过13-C-NMR探测作为蛋白酶抑制剂的活性， 确定解决方案中可能充当 过渡态类似物。 %%% 有了这个标准格兰特RUI奖，合成有机 该项目支持Rose M博士的研究。麦康奈尔 大学自然科学系 阿肯色州，蒙蒂塞洛。 麦康奈尔教授会让她 ~（13）C标记亮肽素的制备研究 衍生物，将通过核磁共振研究，以确定作用 作为蛋白酶抑制剂的化合物。 这项研究是 尤其是大学生的参与。