Development of a Biophysical Source Model to Evaluate Sensitivity of Unipolar and MAP Bioelectrode Recordings in Cardiac Tissue

开发生物物理源模型来评估心脏组织中单极和 MAP 生物电极记录的敏感性

• 批准号: 9309181
• 负责人: Craig Henriquez
• 金额: $ 6万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-15 至 1996-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9309181&HistoricalAwards=false
• 关键词: Development; Biophysical; Source; Model; Evaluate

9309181 Henriquez The objectives of the research initiation grant is to develop a mathematical model of cardiac tissue for evaluating the sensitivity of various types of electrogram recordings at the surface to changes in the underlying spread of electrical activation. Both unipolar and monophasic action potential electrograms will be modeled and two and three dimensional bidomain models of cardiac tissue will be used. This study will include complex activation fronts including reentry. This research is important since it could lead to the improvement of the utility of extracellular measurements for a variety of electrophysiological procedures. ***

9309181 Henriquez这项研究启动基金的目的是建立一个心脏组织的数学模型，用于评估不同类型的表面电图记录对潜在电激活扩散变化的敏感性。将对单极和单相动作电位电图进行建模，并使用心脏组织的二维和三维双域模型。这项研究将包括包括再入在内的复杂激活前沿。这项研究很重要，因为它可以改善各种电生理程序的细胞外测量的效用。＊＊＊