Multinuclear NMR and IR Spectroscopy of Peroxometal-MediatedBromide Oxidation: Modeling Vanadium Bromoperoxidase

过氧金属介导的溴化物氧化的多核核磁共振和红外光谱：模拟钒溴过氧化物酶

• 批准号: 9309944
• 负责人: Martha Reynolds
• 金额: $ 1.8万
• 依托单位: Colgate University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-01 至 1995-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9309944&HistoricalAwards=false
• 关键词: Multinuclear; NMR; IR; Spectroscopy; Peroxometal

This award in the Research Planning Grant for women program is made by the Chemistry Division to Dr. Martha Reynolds of the Chemistry Department, Colgate University. Multinuclear NMR and IR spectroscopies will be used to probe metal-catalyzed oxidative brominations. During the planning period, Dr. Reynolds will spend an extended period in the laboratories of Dr. Alison Butler of the University of California at Santa Barbara learning the needed instrumental techniques and assessing the feasibility of these mthods for studying the oxidation of bromide by peroxometal complexes. This research will form the basis for subsequent work on synthetic analogues of the enzyme vanadium bromoperoxidase. The project is relevant to halogenation reactions widely used for organic synthesis by the pharaceutical industry and to studies of atmospheric bromoform.

这个女性研究计划资助项目的奖项是由化学部门颁发给科尔盖特大学化学系的玛莎·雷诺兹博士的。多核核磁共振和红外光谱将用于探测金属催化的氧化溴化反应。在规划期间，雷诺兹博士将在加州大学圣巴巴拉分校艾莉森·巴特勒博士的实验室里度过一段较长的时间，学习所需的仪器技术，并评估这些方法用于研究溴被过氧化物络合物氧化的可行性。这项研究将为后续合成溴过氧化物钒酶类似物的工作奠定基础。该项目涉及制药工业中广泛用于有机合成的卤化反应和大气溴仿的研究。