Phos-Ligation: A powerful new tool for chemoselective protein modification

磷酸连接：化学选择性蛋白质修饰的强大新工具

• 批准号: DE230100634
• 负责人: Dr Leo Corcilius
• 金额: $ 28.9万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-16 至 2026-01-15
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE230100634
• 关键词: Phos; Ligation; powerful; new; tool

The project aims to develop a powerful new method for the generation of pure modified proteins. Tools for modification of proteins are integral to the study of protein structure and function as well as the commercial production of biopharmaceuticals. The extremely cost effective and operationally simple chemistry that will be developed in this project will overcome a number of pitfalls of currently available methods for protein modification, and will therefore deliver substantial technological innovation to both academia and industry. Through domestic and international collaboration, this new technology will be applied to study proteins involved in the defence of wheat against fungal rust disease and in inflammatory signalling in humans.

该项目旨在开发一种功能强大的新方法来产生纯修饰蛋白质。蛋白质修饰工具对于蛋白质结构和功能的研究以及生物药物的商业生产都是不可或缺的。该项目将开发的极具成本效益和操作简单的化学将克服目前可用的蛋白质修饰方法的一些缺陷，因此将为学术界和工业界带来实质性的技术创新。通过国内和国际合作，这项新技术将被应用于研究小麦抵御真菌锈病和人类炎症信号的蛋白质。