Phos-Ligation: A powerful new tool for chemoselective protein modification

该项目旨在开发一种强大的新方法来生成纯修饰蛋白。蛋白质修饰工具是蛋白质结构和功能研究以及生物制药商业生产不可或缺的一部分。在这个项目中开发的极具成本效益和操作简单的化学方法将克服目前可用的蛋白质修饰方法的许多缺陷，因此将为学术界和工业界带来实质性的技术创新。通过国内和国际合作，这项新技术将应用于研究小麦抵抗真菌锈病和人类炎症信号的蛋白质。

The project aims to develop a powerful new method for the generation of pure modified proteins. Tools for modification of proteins are integral to the study of protein structure and function as well as the commercial production of biopharmaceuticals. The extremely cost effective and operationally simple chemistry that will be developed in this project will overcome a number of pitfalls of currently available methods for protein modification, and will therefore deliver substantial technological innovation to both academia and industry. Through domestic and international collaboration, this new technology will be applied to study proteins involved in the defence of wheat against fungal rust disease and in inflammatory signalling in humans.