Surface ligation of nanomaterials for biomedical applications

用于生物医学应用的纳米材料的表面连接

• 批准号: DP230100709
• 负责人: Prof Irene Yarovsky
• 金额: $ 27.91万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230100709
• 关键词: Surface; ligation; nanomaterials; biomedical; applications

The project aims to explore the synergistic effects co-ligands for target recognition and biofouling protection in nanoparticle surface patterns to enable practical atomic scale precision engineering of efficient and biofouling resistant nanosensors. The project will fundamentally characterise interfacial interactions and dynamics of ligated nano-surfaces and biomolecules via advanced computer modelling. Outcomes should include practical molecular design guidelines for functional ligands and predicted optimal patterns for combining functional and antifouling ligands on gold nanomaterials for biosensing technologies. The advanced predictive modelling capabilities will facilitate future practical engineering of efficient biomedical devices.

该项目旨在探索纳米颗粒表面图案中目标识别和生物污垢保护的协同配体的协同效应，以实现高效且抗生物污垢纳米传感器的实用原子级精密工程。该项目将通过先进的计算机建模从根本上表征连接纳米表面和生物分子的界面相互作用和动力学。 结果应包括功能配体的实用分子设计指南，以及将功能配体和防污配体结合在金纳米材料上用于生物传感技术的预测最佳模式。先进的预测建模功能将有助于未来高效生物医学设备的实际工程。