Neurobiology of Identified Peptidergic Neurons

已识别肽能神经元的神经生物学

• 批准号: 9314537
• 负责人: Nathan Tublitz
• 金额: $ 59.19万
• 依托单位: University of Oregon Eugene
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-04-15 至 1999-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9314537&HistoricalAwards=false
• 关键词: Neurobiology; Identified; Peptidergic; Neurons

9314537 Tublitz Neuropeptides, small proteinaceous molecules released from nerve cells, have profound effects both on the brain and peripheral tissues. They have been implicated in a variety of neural functions, ranging from controlling movements to transmitting sensory information such as pain. These chemicals are also involved in more long-term behavioral changes such as learning and memory, arousal and various emotional states. Despite their critical importance, little is known about the cellular and molecular mechanisms underlying peptide action. Dr. Tublitz's research is directed towards finding these answers. He is concentrating on a family of neuropeptides, the Cardioacceleratory Peptides (CAPs), that modulate several different tissues, including the heart, gut and brain. In his previous NSF research, Dr. Tublitz demonstrated that these neuropeptides modulate four different, developmentally-specific behaviors, each having a distinctive set of characteristics resulting in very different physiological and/or behavioral consequences. Moreover, he identified the cells that produce the CAPs and their targets. Dr. Tublitz will now determine how these neuropeptides affect their targets at the molecular level as well as to identify the genes that code producing the peptide regulate its levels. The results from this basic research will lead to a better understanding of how neurochemicals function to modulate nerve cell activity and subsequently, behavior. ***

9314537 Tublitz神经肽是神经细胞释放的小蛋白分子，对大脑和周围组织都有深远的影响。它们与多种神经功能有关，从控制运动到传递感觉信息(如疼痛)。这些化学物质还涉及更长期的行为变化，如学习和记忆、唤醒和各种情绪状态。尽管它们至关重要，但人们对多肽作用的细胞和分子机制知之甚少。图布里茨博士的研究旨在找到这些答案。他正专注于一系列神经肽，即心脏加速肽(CAPS)，它们调节着几种不同的组织，包括心脏、肠道和大脑。在他之前的NSF研究中，Tublitz博士证明，这些神经肽调节四种不同的、特定于发育的行为，每种行为都有一组不同的特征，导致非常不同的生理和/或行为后果。此外，他还确定了产生帽子的细胞和它们的目标。Tublitz博士现在将确定这些神经肽如何在分子水平上影响它们的靶标，以及识别编码产生调节其水平的多肽的基因。这项基础研究的结果将有助于更好地理解神经化学物质是如何调节神经细胞活动并随后调节行为的。***