Neurobiology of Peptidergic Neurons

肽能神经元的神经生物学

• 批准号: 9009155
• 负责人: Nathan Tublitz
• 金额: $ 32.18万
• 依托单位: University of Oregon Eugene
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-10-15 至 1995-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9009155&HistoricalAwards=false
• 关键词: Neurobiology; Peptidergic; Neurons

Neuropeptides are small proteinaceous molecules which are involved in a variety of brain roles, ranging from controlling movements to transmitting sensory information such as pain. These chemicals are also implicated in more long-term behavioral changes such as learning and memory, arousal and various emotional states. Although much is known about the behavioral effects of neuropeptides, relatively little is understood about how these neurochemicals cause changes at the cellular and molecular levels. Unfortunately, these sorts of physiological studies are not currently feasible in mammals because of technical difficulties and that the mammalian brain is exceedingly centralized and complex. To overcome these problems, Dr. Tublitz has capitalized on relatively simple nervous system of invertebrates. He concentrates on a family of neuropeptides, the Cardioacceleratory Peptides (CAPs), that modulate several different tissues, including the heart, gut and CNS. Dr. Tublitz will examine the physiology of individual cells which synthesize and release the CAPs. He will examine why the number of neuropeptide neurons change during the animal's lifetime. Moreover, Dr. Tublitz will determine the molecular mechanisms by which the CAPs exert the powerful and long-lasting effects upon the target tissues. These investigations, currently possible only in simple invertebrate preparations, will likely provide new and important information about neuropeptide function that will be applicable to all species, including humans. This work will lead to a better understanding of how the chemicals in the brain interact with each other and with the brain's nerve cells to modify behavior.

神经肽是小的蛋白质分子， 参与了各种各样的大脑角色，从控制 运动到传递感觉信息，如疼痛。 这些化学物质也与更长期的行为有关。 学习和记忆，唤醒和各种变化 情绪状态 尽管我们对这种行为已经有了很多了解， 神经肽的作用，相对较少了解 这些神经化学物质如何引起细胞的变化， 分子水平。 不幸的是，这些生理上的 目前在哺乳动物中的研究是不可行的，因为 技术上的困难，哺乳动物的大脑 非常集中和复杂。 为了克服这些问题， Tublitz博士利用相对简单的神经系统 无脊椎动物。 他专注于神经肽家族， 调节几种细胞增殖加速肽（CAPs） 不同的组织，包括心脏，肠道和中枢神经系统。 Tublitz博士 将研究单个细胞的生理学 并释放CAP。 他将研究为什么 神经肽神经元在动物的一生中会发生变化。 此外，Tublitz博士将确定分子机制， 这些CAP会产生强大而持久的影响， 目标组织。 这些调查，目前可能 只有在简单的无脊椎动物制剂，将可能提供新的 以及神经肽功能的重要信息， 适用于所有物种，包括人类。 这项工作将 从而更好地理解大脑中的化学物质 相互作用并与大脑的神经细胞相互作用， 改变行为。