Biocatalytic Conversion of Aromatic Waste into Useful Compounds

9315684 Hudlicky这项研究的重点将是四个方面。 新的芳香族底物将被筛选用于假单胞菌Putida 39/D的氧化，以拓宽该方法的适用性。 高锰酸钾氧化二烯将被研究作为臭氧分解的替代方案。 糖、环醇、鞘脂和生物碱的合成将证明生物催化策略的有效性，第四，将评估每种制剂的试剂和废物输出的质量平衡，以最大限度地减少生产过程中产生的有机副产物。 有了这个环境友好的化学合成和加工奖，合成有机计划正在支持弗吉尼亚理工学院和州立大学化学系的Tomas Hudlicky博士的研究。 Hudlicky教授将与Genencor International合作，重点研究如何从源头上减少污染。 该策略基于这样的假设，即，代替焚烧或其他处置手段，均质废物或溶剂将经受由恶臭假单胞菌39/D进行的微生物氧化，以产生芳烃顺式二醇，其理想地适合于短时间和环境友好的转化为有用的有机化合物。 ***

9315684 Hudlicky The focus of this research will be fourfold. New aromatic substrates will be screened for oxidation by Pseudomonas Putida 39/D to broaden the applicability of this method. Potassium permanganate oxidation of dienes will be investigated as an alternative to ozonolysis. Syntheses of sugars, cyclitols, sphingolipids and alkaloids will demonstrate the efficiency of the biocatalytic strategy and fourth, mass balance of reagents and waste output will be assessed for each preparation in order to minimize organic byproducts produced during manufacture. With this Environmentally Benign Chemical Synthesis and Processing award, the Synthetic Organic Program is supporting the research of Dr. Tomas Hudlicky of the Department of Chemistry at the Virginia Polytechnic Institute and State University. Professor Hudlicky, collaborating with Genencor International, will focus his work on developing a new strategy for the reduction of pollution at its source. The strategy rests on the assumption that, instead of incineration or other means of disposal, homogeneous waste or solvents would be subjected to microbial oxidation by Pseudomonas Putida 39/D to produce arene cis-diols which are ideally suited for short and environmentaly benign conversions to useful organic compounds. ***