Biocatalytic Conversion of Aromatic Waste into Useful Compounds

本研究的重点有四个方面。将筛选新的芳香族底物进行恶臭假单胞菌39/D的氧化，以扩大该方法的适用性。高锰酸钾氧化双烯将作为臭氧氧化的替代方法进行研究。糖、环醇、鞘糖脂和生物碱的合成将证明生物催化策略的有效性，第四，将评估每种制剂的试剂和废物产量的质量平衡，以最大限度地减少生产过程中产生的有机副产品。有了这个环境友好的化学合成和加工奖，有机合成计划正在支持佛罗里达大学化学系的托马斯·哈德里奇博士的研究。哈德利基教授将与Genencor International合作，将重点放在开发从源头减少污染的新战略上。该战略基于这样的假设，即均质废物或溶剂不是焚烧或其他处置手段，而是经过恶臭假单胞菌39/D的微生物氧化，以产生芳烃顺式二醇，这种顺式二醇非常适合于短期和对环境无害的转化为有用的有机化合物。

The foci of this research are fourfold. New aromatic substrates will be screened for oxidation by Pseudomonas Putida 39/D to broaden the applicability of this method. Potassium permanganate oxidation of dienes will be investigated as an alternative to ozonolysis. Syntheses of sugars, cyclitols, sphingolipids and alkaloids will demonstrate the efficiency of the biocatalytic strategy and fourth, mass balance of reagents and waste output will be assessed for each preparation in order to minimize organic byproducts produced during manufacture. With this Environmentally Benign Chemical Synthesis and Processing award, the Organic Synthesis Program is supporting the research of Dr. Tomas Hudlicky of the Department of Chemistry at the University of Florida. Professor Hudlicky, collaborating with Genencor International, will focus his work on developing new strategy for the reduction of pollution at its source. The strategy rests on the assumption that, instead of incineration or other means of disposal, homogeneous waste or solvents would be subjected to microbial oxidation by Pseudomonas Putida 39/D to produce arene cis-diols which are ideally suited for short and environmentally benign conversions to useful organic compounds