Solvatochromic Studies of Solvated Stationary Phases

9318484霍克里奇该奖项是由分析和表面化学计划颁发的，以支持萨拉·鲁坦博士的研究。本研究旨在阐明溶剂化固定相在反相液相色谱中的作用。这将通过使用其紫外可见吸收最大值取决于其分子环境的指示剂来实现。将确定描述偶极/极化率、氢键酸性和氢键碱性的溶致变色参数。用漫反射光谱可获得烷基链衍生物固定相粒子的混合水/有机相中各种指示剂的光谱。保留在主体流动相中的染料分子的干扰将使用自适应过滤技术消除。在一项相关研究中，因子分析方法将被用来帮助开发基于这些溶致变色参数的无限稀释活度系数和溶液热的预测方法。改进的建模技术和描述色谱相化学的参数的发展相结合，最终应该使研究人员能够预测反相液相色谱中溶质的保留特性。这一能力将在广泛的工业和医学相关分离中发挥重大作用，并可能被证明对其他界面系统的表征很有价值。

9318484 Hawkridge This award is made in the Analytical and Surface Chemistry Program in support of the research of Dr. Sarah Rutan. The research is aimed at elucidating the role of the solvated stationary phase in reversed phase liquid chromatography. This will be achieved through the use of indicators whose UV-visible absorbance maxima are dependent on their molecular environments. Solvatochromic parameters describing the dipolarity/polarizability, hydrogen bond acidity and hydrogen bond basicity will be determined. Spectra of various indicators in mixed aqueous/organic supensions of stationary phase particles which have been derivatized with alkyl chains will be obtained using diffuse reflectance spectroscopy. Interferences from dye molecules that remain in the bulk mobile phase will be eliminated using adaptive filtering techniques. In a related study, factor analysis methods will be used to aid in the development of methods for the prediction of infinite dilution activity coefficients and heats of solution, based on these solvatochromic parameters. The combination of improved modeling techniques and the development of parameters describing the chemistry of the chromatographic phases should ultimately allow the researcher to predict retention characteristics for solutes in reversed phase liquid chromatography. This capability will be of significant benefit across a broad range of industrial and medically related separations and may also prove valuable to the characterization of other interfacial systems.