RUI: The Modulatory Role of pH in Hippocampal Neuron Metabolic Responses to Challenge

RUI：pH 在海马神经元对挑战的代谢反应中的调节作用

• 批准号: 9319433
• 负责人: Kathleen Susman
• 金额: $ 14.06万
• 依托单位: Vassar College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-01 至 1998-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9319433&HistoricalAwards=false
• 关键词: RUI; Modulatory; Role; pH; Hippocampal

9319433 Susman Acid-base balance, or pH homeostasis, is crucial for the proper function of many organs within the body, including the brain. However, despite the general agreement that pH homeostasis is crucial for brain function, little is known about the impact of changes in pH on nerve cell (neuron) functioning. It was only recently that scientists recognized that changes in brain pH play a role in neuron signalling. Neurotransmitters, released from neurons in response to an electrical signal, influence brain pH. Further, brain pH influences the response of neurons to neurotransmitters. These findings indicate that changes in pH modulate neuron electrical functioning. It is well-known in other systems that pH changes affect many cellular processes, including energy and protein metabolism. Despite indications that pH affects neuronal function, little is known about the role of pH changes in metabolism of neurons or of how pH is regulated in neurons. Current research explores the relationships among pH, energy metabolism and protein metabolism in slices from the region of the brain implicated in learning and memory, the hippocampus. We assess the impact of brief changes in pH on neuronal metabolic responses to neurotransmitter stimulation and to energy challenges. Results from this study will provide important information about the role of changes in brain pH in several important aspects of neuronal function, particularly protein and energy metabolism, and will provide new information about pH regulation in the mammalian brain. ***

小行星9319433 酸碱平衡，或pH稳态，对身体内许多器官的正常功能至关重要，包括大脑。 然而，尽管人们普遍认为pH稳态对大脑功能至关重要，但人们对pH变化对神经细胞（神经元）功能的影响知之甚少。 直到最近，科学家们才认识到大脑pH值的变化在神经元信号传导中起着重要作用。 神经递质，从神经元释放响应电信号，影响大脑pH值。 此外，大脑pH值影响神经元对神经递质的反应。 这些发现表明，pH值的变化调节神经元电功能。 众所周知，在其他系统中，pH值的变化会影响许多细胞过程，包括能量和蛋白质代谢。 尽管有迹象表明pH值影响神经元功能，但对pH值变化在神经元代谢中的作用或pH值如何在神经元中调节知之甚少。 目前的研究探索了与学习和记忆有关的大脑区域海马切片中pH值、能量代谢和蛋白质代谢之间的关系。 我们评估pH值的短暂变化对神经递质刺激和能量挑战的神经元代谢反应的影响。 这项研究的结果将提供重要的信息，在神经元功能的几个重要方面，特别是蛋白质和能量代谢的作用，脑pH值的变化，并将提供新的信息pH值调节哺乳动物大脑。 ***