EMRSHN: Exploring the Modulatory Role of Sec Hormones Along the Neuromechanical Axis in Females

EMRSHN：探索 Sec 激素对女性神经力学轴的调节作用

• 批准号: 10394668
• 负责人: Yasin Yousef Dhaher
• 金额: $ 5.63万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10394668
• 关键词: Acute; Biological; Biopsy; Characteristics; Estradiol; Exercise; Female; Gene Expression; Gene Proteins; Gonadal Steroid Hormones; Histology; Hormones; Libido; Magnetic Resonance Spectroscopy; Menstrual cycle; Monitor; Muscle; Muscle Fibers; Neuromechanics; Operative Surgical Procedures; Parents; Patients; Phenotype; Prevention strategy; Role; Skeletal Muscle; Time; Work; injury prevention; musculoskeletal injury; neuromuscular; recruit; sex disparity

Project Summary Building off of our current R01, we propose to characterize the effect of systemic hormone concentrations on basic skeletal muscle characteristics. Initially, young and otherwise healthy female surgical patients will be recruited to determine an associative mapping between muscle fiber composition and E2 concentration using histology and protein/gene expression of skeletal muscle biopsies. Next, young and healthy female subjects would be recruited to identify potential muscle fiber composition changes over a limited time window during the menstrual cycle, using a state-of-the-art 7 Tesla scanner to perform magnetic resonance spectroscopy. Finally, young and healthy female subjects would be recruited to identify the potential effect of the endocrinological state on muscle plasticity by monitoring circulating myomiRs and muscle activity during exercise. If successfully completed, these aims would reveal a relationship between a subject’s endocrinological state and acute changes in basic muscle phenotype and the associated changes in neuromuscular control. Taken together these aims have the potential to elucidate the underlying biological mechanisms that may drive the sex-disparity seen in musculoskeletal injury and to guide future research in injury prevention strategies.

项目总结