Water Soluble Phosphines for Organometallic Chemistry and Catalysis in the Aqueous Phase

Brian E. Hanson博士，弗吉尼亚理工学院化学系，得到无机、生物无机和有机金属化学项目的支持，从事水溶性磷化氢的合成和在水中溶解或形成胶束的催化剂的开发。含有磺化芳基取代基的膦可以通过几种途径制备。空间和电子参数将有很大的变化，并且将制备具有类似于目前用于催化剂的磷化氢的参数的样品。这些新制备的水溶性或表面活性膦将用于形成催化剂，这些催化剂将对氢甲酰化，氢化和/或水中不对称合成具有活性。可以在水溶液中进行的化学过程由于水的无毒、无污染的性质而具有潜在的环境优势。然而，在许多工业过程中使用的催化剂不溶解，因此不能用于水基工艺。在这个项目中，将设计在水介质中运行的催化剂，以工业上重要的氢甲酰化，氢化和不对称合成为目标。

9319881 Hanson Virginia Polytechnic Inst. Dr. Brian E. Hanson, Chemistry Department, Virginia Polytechnic Institute, is supported by the Inorganic, Bioinorganic, and Organometallic Chemistry Program for the synthesis of water soluble phosphines and to develop catalysts which dissolve or form micelles in water. Phosphines containing sulfonated aryl substituents will be prepared by several routes. The steric and electronic parameters will be widely varied and examples will be prepared with parameters similar to those of phosphines currently being used in catalysts. These newly prepared water soluble or surface active phosphines will be used to form catalysts which will be active for hydroformylation, hydrogenation, and/or asymmetric synthesis in water. Chemical processes which can be carried out in an aqueous solution have potential environmental advantages arising from the non-toxic, non-polluting nature of water. However, catalysts which are used in many industrial processes do not dissolve and consequently cannot be used in water based processes. In this project catalysts which will operate in aqueous media will be devised, with those for industrially important hydroformylation, hydrogenation, and asymmetric synthesis being targeted.