Water Soluble Phosphines for Organometallic Chemistry and Catalysis in the Aqueous Phase

9319881汉森弗吉尼亚理工学院博士布赖恩E。Hanson，弗吉尼亚理工学院化学系，由无机，生物无机和有机化学计划支持，用于合成水溶性膦，并开发在水中溶解或形成胶束的催化剂。含有磺化芳基取代基的膦将通过几种途径制备。空间和电子参数将广泛变化，并且将用与目前在催化剂中使用的膦类似的参数制备实施例。这些新制备的水溶性或表面活性膦将用于形成催化剂，所述催化剂对于在水中的加氢、氢化和/或不对称合成是活性的。 可以在水溶液中进行的化学过程具有潜在的环境优势，这是由于水的无毒、无污染的性质。然而，在许多工业过程中使用的催化剂不溶解，因此不能用于水基过程。在这个项目中，将设计在水介质中运行的催化剂，目标是工业上重要的加氢，氢化和不对称合成。

9319881 Hanson Virginia Polytechnic Inst. Dr. Brian E. Hanson, Chemistry Department, Virginia Polytechnic Institute, is supported by the Inorganic, Bioinorganic, and Organometallic Chemistry Program for the synthesis of water soluble phosphines and to develop catalysts which dissolve or form micelles in water. Phosphines containing sulfonated aryl substituents will be prepared by several routes. The steric and electronic parameters will be widely varied and examples will be prepared with parameters similar to those of phosphines currently being used in catalysts. These newly prepared water soluble or surface active phosphines will be used to form catalysts which will be active for hydroformylation, hydrogenation, and/or asymmetric synthesis in water. Chemical processes which can be carried out in an aqueous solution have potential environmental advantages arising from the non-toxic, non-polluting nature of water. However, catalysts which are used in many industrial processes do not dissolve and consequently cannot be used in water based processes. In this project catalysts which will operate in aqueous media will be devised, with those for industrially important hydroformylation, hydrogenation, and asymmetric synthesis being targeted.