NSF Young Investigator: Host-Guest Molecular Recognition in the Gas-Phase

这个NSF的年轻研究者奖从有机动力学计划 支持得克萨斯大学迪尔登教授的工作， 阿灵顿。冠醚的固有分子识别性能 以及金属和分子离子的相关配体 在气相中使用离子回旋共振和串联质量 光谱技术将使用基质辅助激光器 解吸和电喷雾电离技术。的具体领域 关注（a）冠醚/碱金属主客体的鉴定 系统，（B）单电荷碱土金属一卤化物和铵 阳离子，（c）手性主客体系统，（d）生物离子载体， 酶/底物系统和环糊精。 %%% 有了这个NYI奖，大卫教授D。Dearden's将进行气相 研究以确定内在因素和 溶剂化在控制分子识别中的作用。通过消除 溶剂和反离子的相互作用， 可以直接探测主机和来宾。这项工作将利用 基质辅助激光解吸和电喷雾电离 技术，使一个大大扩展的范围内的群众可检测的 质谱分析法来这项工作旨在发展化学和光谱 探针来确定三维离子结构。

This NSF Young Investigator Award from the Organic Dynamics Program supports the work of Professor Dearden at the University of Texas at Arlington. Intrinsic molecular recognition properties of crown ethers and related ligands for metal and molecular ions will be investigated in the gas phase using ion cyclotron resonance and tandem mass spectrometric techniques. Use will be made of the matrix-assisted laser desorption and electrospray ionization techniques. The specific areas concern (a) the identification of crown ether / alkali metal host-guest systems, (b) singly-charged alkaline earth monohalides and ammonium cations, (c) chiral host-guest systems, (d) biological ionophores, enzyme / substrate systems, and cyclodextrins. %%% With this NYI award Professor David D. Dearden's will conduct gas phase studies to determine both the intrinsic factors and the role of solvation in governing molecular recognition. By eliminating the effects arising from solvents and counterions, the interaction between hosts and guests can be probed directly. This work will make use of matrix-assisted laser desorption and electrospray ionization techniques, enabling a greatly extended range of masses detectable by mass spectrometry. This work aims to develop chemical and spectroscopic probes to determine 3-dimensional ion structures.