NSF Young Investigator/Electrochemical Microsensors and Microcolumn Separation: Analysis of Peptide Neuro- Transmitters and Hormones

国家科学基金会青年研究者项目在 分析和表面化学的一般领域， 生物分析化学的一个分支。 在五年任期内， 肯尼迪教授和他的学生将继续努力， 电化学微传感器和微柱的发展 分离，如毛细管色谱法和毛细管 电泳，用于肽的研究 神经递质和激素。 这项研究的一个主要目标是 检测和连续监测zeptomole量 肽在单细胞和体内毫秒时间 分辨率和亚微米空间分辨率。 %%% 该项目目标的成功实现应 促进生物分析化学的广泛发展， 特别是微量神经肽的分析， 荷尔蒙 所提出的方法，包括微量测序 和微柱分离，将允许检测肽 在大脑的特定区域或单个细胞中。

This National Science Foundation Young Investigator project is in the general area of analytical and surface chemistry and in the subfield of bioanalytical chemistry. During the five-year tenure of this award, Professor Kennedy and his students will pursue the development of electrochemical microsensors and microcolumn separations, such as capillary chromatography and capillary electrophoresis, for the investigation of peptide neurotransmitters and hormones. A major goal of the research is the detection and continuous monitoring of zeptomole quantities of peptides at single cells and in vivo with millisecond time resolution and submicron spatial resolution. %%% The successful attainment of the goals of this project should enable the broad advancement of bioanalytical chemistry, in particular the analysis of minute quantities of neuropeptides and hormones. The proposed methods, including microscale sequencing and microcolumn separations, will allow the detection of peptides in specific regions of the brain or in single cells.