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Trifunctional folate-metabolizing enzyme MTHFD1: impact on birth defects and cancer

Trifunctional folate-metabolizing enzyme MTHFD1: impact on birth defects and cancer
三功能叶酸代谢酶 MTHFD1：对出生缺陷和癌症的影响
批准号：
223680
负责人：
Rozen Rima
金额：
$43.62万
依托单位：
Research Institute of the McGill University Health Centre
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2011
资助国家：
加拿大
项目状态：
已结题
起止时间：
2011-03-01 至 2016-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=223680&lang=en
关键词：
Cancer Congenital Heart Defects Folate Genetics Mthfd1 Neural Tube Defects

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中文摘要
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英文摘要
Low dietary folate has been well-established as a risk factor for the development of birth defects and cancer. Variations in folate pathway genes have been identified that also increase the risk for these disorders. Folate is required to provide the build
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Supplementation of folic acid or methyltetrahydrofolate to reduce developmental anomalies in a new mouse model for the MTHFR 677C>T polymorphism
Adequate intake of choline in pregnancy may be critical for MTHFD1 synthetase deficiency, a common genetic variant in folate metabolism
Methylenetetrahydrofolate reductase (MTHFR) and multifactorial diseases
19.98CIHR Health Professional Student Research Award vouchers.
  • 批准号：
    234961
  • 项目类别：
    Summer Student Programs
  • 资助金额：
    $6.19万
  • 财政年份：
    2012
  • 负责人：
    Rozen Rima
  • 依托单位：
    McGill University
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