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Adequate intake of choline in pregnancy may be critical for MTHFD1 synthetase deficiency, a common genetic variant in folate metabolism

Adequate intake of choline in pregnancy may be critical for MTHFD1 synthetase deficiency, a common genetic variant in folate metabolism
怀孕期间摄入足够的胆碱可能对于 MTHFD1 合成酶缺乏症至关重要，MTHFD1 合成酶缺乏症是叶酸代谢中常见的遗传变异
批准号：
368202
负责人：
Rozen Rima
金额：
$46.53万
依托单位：
Research Institute of the McGill University Health Centre
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2017
资助国家：
加拿大
项目状态：
已结题
起止时间：
2017-09-01 至 2022-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=368202&lang=en
关键词：
Choline Folate Gene-Nutrient Interactions Genetic Polymorphism Mthfd1 Synthetase Deficiency Pregnancy Complications

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英文摘要
Folate and choline are important nutrients required to support healthy pregnancies. Inadequate intake of these nutrients before and during pregnancy can increase the risk of birth defects and other pregnancy complications. Folate is a critical vitamin tha
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Supplementation of folic acid or methyltetrahydrofolate to reduce developmental anomalies in a new mouse model for the MTHFR 677C>T polymorphism
Methylenetetrahydrofolate reductase (MTHFR) and multifactorial diseases
19.98CIHR Health Professional Student Research Award vouchers.
  • 批准号：
    234961
  • 项目类别：
    Summer Student Programs
  • 资助金额：
    $6.19万
  • 财政年份：
    2012
  • 负责人：
    Rozen Rima
  • 依托单位：
    McGill University
Trifunctional folate-metabolizing enzyme MTHFD1: impact on birth defects and cancer
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