RUI: Mapping Polygenes that Control Wing Form in Drosophila Melanogaster, Using Transposons

RUI：使用转座子绘制控制果蝇翅膀形状的多基因图谱

• 批准号: 9407005
• 负责人: Kenneth Weber
• 金额: $ 34.08万
• 依托单位: University of Southern Maine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-15 至 1999-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9407005&HistoricalAwards=false
• 关键词: RUI; Mapping; Polygenes; Control; Wing

Weber 9407005 This study will investigate the genes that control the growth of localized groups of cells during the growth of organisms, to produce the final shapes and proportions of specific parts in the adult. The project will study these genes by using many replicated measurements of the proportions of wings in Drosophila melanogaster (the common fruit fly), combined with methods of marking and identifying chromosome regions so that the effect of each region on the adult wing shape can be distinguished from effects of other chromosome regions. By this approach, a complete map of the chromosomes will be assembled, showing the locations of the genes which control the shape of the wing. This information will help to guide the search for specific DNA sequences with well-defined localized effects on shape. Since many basic genetic discoveries with applicability to humans have been made using Drosophila, this investigation may also shed light on how genes control form in humans. The wing of the fruit fly provides ideal material for such studies, because it can easily be projected like a slide to give highly magnified image on a large computerized measuring pad.

韦伯9407005 这项研究将调查在生物体生长过程中控制局部细胞群生长的基因，以产生成年人特定部分的最终形状和比例。 该项目将通过对果蝇（普通果蝇）翅膀比例的多次重复测量，结合标记和识别染色体区域的方法来研究这些基因，以便将每个区域对成年翅膀形状的影响与其他染色体区域的影响区分开来。 通过这种方法，一个完整的染色体图谱将被组装，显示控制翅膀形状的基因的位置。 这些信息将有助于指导对特定DNA序列的搜索，这些DNA序列对形状有明确的局部影响。 由于许多适用于人类的基本遗传学发现都是使用果蝇进行的，因此这项研究也可能揭示基因如何控制人类的形式。 果蝇的翅膀为这类研究提供了理想的材料，因为它可以像幻灯片一样很容易地投影到大型计算机测量板上，以提供高度放大的图像。