Japan JSPS Program: Models of Nucleotide Substitution and the Demographic History of Natural Populations

日本 JSPS 计划：核苷酸替代模型和自然种群的人口统计历史

• 批准号: 9408071
• 负责人: John Wakeley
• 金额: $ 0.67万
• 依托单位: Individual Award
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-01 至 1995-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9408071&HistoricalAwards=false
• 关键词: Japan; JSPS; Program; Models; Nucleotide

9408071 Wakeley This award supports a 12-month Japan Society for the Promotion of Science Postdoctoral Fellowship for Dr. John Wakeley, Department of Integrative Biology, University of California, Berkeley, at the Department of Population Genetics, National Institute of Genetics, Mishima, Japan. Dr. Wakeley will work with Dr. Fumio Tajima on a research project entitled "Models of Nucleotide Substitution and the Demographic History of Natural Populations." Dr. Wakeley will pursue two main areas of research in Japan. The first involves inferences about the pattern of DNA sequence evolution. The investigators will develop a computer-based method of quantifying variation in the rate of nucleotide substitution among sites in DNA sequences. The method involves the random placement of hypothetical nucleotide substitutions on a genealogy relating the sequences. The second area involves developing statistical approaches to making inferences about the demographic history of populations. Having recently derived the variance of the average number of nucleotide differences among pairs of sequences in a sample from two populations that exchange migrants, and comparing this variance to previously published results for two populations that have been completely isolated from each other for some length of time, Dr. Wakeley found that the variance is greater under migration than under isolation. Thus, he plans to develop a test to distinguish these two biologically interesting cases. ***

小行星9408071 该奖项支持为加州大学伯克利分校综合生物学系John Wakeley博士在日本三岛国立遗传学研究所群体遗传学系提供为期12个月的日本科学促进协会博士后研究金。 Wakeley博士将与Fumio Tajima博士合作开展一项名为“核苷酸替代模型和自然种群的人口统计学历史”的研究项目。" Wakeley博士将在日本从事两个主要研究领域。 第一个是关于DNA序列进化模式的推论。 研究人员将开发一种基于计算机的方法来量化DNA序列中不同位点之间核苷酸取代率的变化。 该方法涉及在与序列相关的系谱上随机放置假设的核苷酸取代。 第二个领域涉及制定统计方法，以推断人口的人口历史。 最近，韦克利博士从两个交换移民的种群中获得了一个样本中序列对之间核苷酸差异的平均数的方差，并将此方差与之前发表的两个完全隔离一段时间的种群的结果进行了比较，他发现迁移的方差大于隔离。 因此，他计划开发一种测试来区分这两个生物学上有趣的病例。 ***