Theoretical and Comparative Studies of the Ecology and Evolution of Sexually-Transmitted Diseases

性传播疾病生态学和进化的理论和比较研究

• 批准号: 9408207
• 负责人: Janis Antonovics
• 金额: $ 14.5万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-15 至 1996-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9408207&HistoricalAwards=false
• 关键词: Theoretical; Comparative; Studies; Ecology; Evolution

Antonovics 9408207 The ecological and evolutionary impact of sexually transmitted diseases (STD's) has rarely been studied in a non-medical context; they have been considered a minor type of infectious disease in natural systems. The investigators' initial studies have shown that STD's are abundant within the animal kingdom and that they have many shared characteristics (low disease induced mortality, long span of infectious period, narrow host ranges, sterility, less population cycling). This study will use theoretical models to investigate (a) the factors that influence evolution towards sexual versus other modes of disease transmission, (b) the coevolution of pathogen characteristics and host mating systems, and (c) the effect of spatial structure on stability and evolution of STD's STD's can have important consequences for population regulation and for the evolution of mating systems. The study of their population biology is also relevant for interpreting and predicting the emergence of new diseases. The present study will bear directly on these issues.

Antonovics 9408207 性传播疾病 (STD) 的生态和进化影响很少在非医学背景下进行研究；它们被认为是自然系统中的一种次要传染病。 研究人员的初步研究表明，性传播疾病在动物界中大量存在，并且它们具有许多共同的特征（疾病引起的死亡率低、传染期长、宿主范围窄、不育、种群循环少）。 本研究将使用理论模型来研究（a）影响有性传播与其他疾病传播模式进化的因素，（b）病原体特征和宿主交配系统的共同进化，以及（c）空间结构对性病稳定性和进化的影响性病可能对种群调节和交配系统的进化产生重要影响。 对它们种群生物学的研究也与解释和预测新疾病的出现有关。 本研究将直接涉及这些问题。