RPG: Regulation of Neurogenesis Throughout the Lifespan

小行星9408170 摘要 该项目的长期目标是了解如何将新的脑细胞添加到成人大脑中。 在包括人类在内的哺乳动物中，称为神经元的脑细胞仅在非常早期的发育过程中产生，并且由于损伤或疾病而丢失的神经元无法被替换。 使用动物模型，其中神经元被添加到已经存在的大脑回路中，这些回路对于学习和产生用于交流的声音非常重要，解剖学和行为学研究将解决促进新神经元添加到大脑的生物事件。 了解神经元如何被添加到大脑中可能会导致治疗，这将减轻神经系统疾病的破坏性影响。

9408170 Brown ABSTRACT The long-term objectives of this project are to understand how new brain cells can be added to adult brains. In mammals including humans, brain cells called neurons are created only during very early development, and neurons that are lost as a result of injury or disease cannot be replaced. Using an animal model in which neurons are added to already-existing brain circuits which are important for learning and producing sounds used to communicate, anatomical and behavioral studies will address the biological events that promote the addition of new neurons to the brain. Understanding how neurons may be added to the brain could lead to therapies which would ameliorate the devastating effects of neurological disease.