The Use of Bioadhesive Microspheres to Treat Peptide Ulcer and the Development of a Novel Magnetic Device for the Analysis of Bioadhesive Interaction

9410387 Mathiowitz本申请中提出的研究涉及开发一种新的磁性方法，以研究体外单个聚合物微球与胃肠组织活段之间的生物粘附。 将通过量化保持载铁微球静止所需的磁力来测量粘附力，同时以恒定速率分离粘附组织。 将使用喂食载有不透射线材料的微球的动物的X射线成像来确定微球与体内靶结构接触的位置和持续时间。 该项目的重点是将体外测定的粘附力与体内GI停留时间相关联。 此外，将评价使用生物粘附性微球改善药物向溃疡GI组织的递送。 ***

9410387 Mathiowitz The research proposed in this application is concerned with the development of a new magnetic method to study bioadhesion between individual polymeric microspheres and living segments of gastrointestinal tissue, in vitro. The adhesion forces will be measured by quantifying the magnetic force required to hold an iron-loaded microsphere stationary, while the adherent tissue is separated at a constant rate. X-ray imaging of animals, which have been fed microspheres loaded with radio-opaque materials, will be used to determine the location and duration of contact of the microspheres with target structures, in vivo. A focus of the project will be to correlate adhesive forces determined in vitro with GI residence time in vivo. In addition, the use of bioadhesive microspheres to improve drug delivery to ulcerated GI tissue will be evaluated. ***