Development of a Novel Magnetic Device for the Analysis of Bioadhesive Interactions and the Use of Bioadhesive Microspheres to Treat Peptic Ulcers

9712821 Mathiowitz本研究的目的是开发一种新的基于磁性的生物粘附测量系统，并开发局部生物粘附药物递送系统，其提供治疗肽溃疡的治疗剂的增强的生物利用度。 本研究的目的包括：（1）完成一种新的磁性方法的发展，以研究生物粘附的聚合物微球和活组织，（2）使用这种方法来研究生物粘附的药物释放球的胃肠道组织，（3）跟踪口服给药微球在实验大鼠。 将通过量化保持载铁微球静止所需的磁力来测量粘附力，同时以恒定速率分离粘附组织。 选择用于试验的聚合物，水凝胶和热塑性聚酐，将用于封装和递送两种不同的药物，成纤维细胞生长因子和血小板衍生生长因子，这已被证明是有用的治疗溃疡。 ***

9712821 Mathiowitz The aims of this research are to develop a novel magnetically based system for bioadhesive measurements and to develop local bioadhesive drug delivery systems, which provide enhanced bioavailability of therapeutic agents to treat peptide ulcers. This research includes the objectives: (1) to finalize the development of a new magnetic method to study bioadhesion between polymeric microspheres and living tissue, (2) to use this method to study bioadhesion of drug-delivering spheres to gastrointestinal tissue, and (3) to track orally administered microspheres in experimental rats. The adhesion forces will be measured by quantifying the magnetic force required to hold an iron-loaded microsphere stationary, while the adherent tissue is separated at a constant rate. The polymers selected for trial, hydrogels and thermoplastic polyanhydrides, will be used to encapsulate and deliver two different drugs, fibroblast growth factor and platelet derived growth factor, which have been shown to be useful in the treatment of ulcers. ***