Development of a Novel Magnetic Device for the Analysis of Bioadhesive Interactions and the Use of Bioadhesive Microspheres to Treat Peptic Ulcers

开发用于分析生物粘附相互作用的新型磁性装置以及使用生物粘附微球治疗消化性溃疡

• 批准号: 9712821
• 负责人: Edith Mathiowitz
• 金额: $ 27.91万
• 依托单位: Brown University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-15 至 2001-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9712821&HistoricalAwards=false
• 关键词: Development; Novel; Magnetic; Device; Analysis

9712821 Mathiowitz The aims of this research are to develop a novel magnetically based system for bioadhesive measurements and to develop local bioadhesive drug delivery systems, which provide enhanced bioavailability of therapeutic agents to treat peptide ulcers. This research includes the objectives: (1) to finalize the development of a new magnetic method to study bioadhesion between polymeric microspheres and living tissue, (2) to use this method to study bioadhesion of drug-delivering spheres to gastrointestinal tissue, and (3) to track orally administered microspheres in experimental rats. The adhesion forces will be measured by quantifying the magnetic force required to hold an iron-loaded microsphere stationary, while the adherent tissue is separated at a constant rate. The polymers selected for trial, hydrogels and thermoplastic polyanhydrides, will be used to encapsulate and deliver two different drugs, fibroblast growth factor and platelet derived growth factor, which have been shown to be useful in the treatment of ulcers. ***

9712821 Mathiowitz这项研究的目的是开发一种新的基于磁性的生物黏附测量系统，并开发本地生物黏附药物输送系统，以提高治疗多肽溃疡的治疗剂的生物利用度。本研究的目的包括：(1)最终建立一种新的磁性方法来研究聚合物微球与活体组织之间的生物粘附性；(2)利用该方法来研究给药微球与胃肠道组织的生物粘附性；(3)对实验大鼠口服微球进行示踪。粘附力将通过量化保持铁负载的微球静止所需的磁力来测量，同时以恒定的速度分离附着的组织。选择进行试验的聚合物，水凝胶和热塑性聚酸酐，将用于包裹和输送两种不同的药物，成纤维细胞生长因子和血小板衍生生长因子，这两种药物已被证明对治疗溃疡有用。***