The Inverse Problem of Electrocardiography: New Computational Approaches, Numerical Simulations, and Experimental Verification

心电图反问题：新的计算方法、数值模拟和实验验证

• 批准号: 9410385
• 负责人: Robert Throne
• 金额: $ 27.04万
• 依托单位: University of Nebraska-Lincoln
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-15 至 1998-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9410385&HistoricalAwards=false
• 关键词: Inverse; Problem; Electrocardiography; New; Computational

9410385 Throne The research proposed in this application is concerned with a recently developed generalized eigensystem finite element technique for the inverse problem of electrocardiography will be extended, compared with other existing methods and validated by comparison with experimental results. Preliminary results indicate that the new generalized eigensystem method performs better than existing approaches on a previously reported eccentric spheres model problem with anterior and posterior spherical cap sources. This generalized eigensystem technique will first be applied to the inhomogeneous eccentric spheres problem and then to a realistic human torso model with realistic human epicardial potentials. With both models the effects of errors in estimating the conductivities, errors in the anisotropic properties, and geometrical errors will be examined and compared with previously reported methods. In addition, the techniques will be validated and compared with experimental results from an isolated rabbit heart preparation. Computational issues such as improved spectral finite elements, robustness, accuracy, and efficiency will be considered. ***

9410385王座在本申请中提出的研究涉及最近开发的广义特征系统有限元技术的心电图逆问题将被扩展，与其他现有的方法相比，并通过与实验结果的比较进行验证。 初步结果表明，新的广义本征系统方法比现有的方法在以前报道的偏心球模型问题的前，后球冠源。 这种广义本征系统技术将首先应用于非均匀偏心球问题，然后到一个现实的人体躯干模型与现实的人类心外膜电位。 与这两个模型的影响，在估计的电导率，各向异性性能的误差，和几何误差的误差将被检查和与以前报道的方法进行比较。 此外，该技术将进行验证，并与离体兔心脏制备的实验结果进行比较。 计算问题，如改进的谱有限元，鲁棒性，准确性和效率将被考虑。 ***