Molecular insights into lipid-mediated T cell immunity

脂质介导的 T 细胞免疫的分子见解

• 批准号: DE230101042
• 负责人: Dr Praveena Thirunavukkarasu
• 金额: $ 29.7万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE230101042
• 关键词: Molecular; insights; into; lipid; mediated

This project involves the discovery of novel lipids produced by the microbiome that play a significant role in T cell-mediated immunity. Using a combination of cutting-edge technologies such as mass spectrometry, protein crystallography, immunology and biophysics, this project will elucidate the molecular factors that govern the interaction between the identified lipids and T cells. This innovative research will provide fundamental insights into the recognition mechanism of lipids by T cells at a molecular level, thus broadening our knowledge in the field of biological sciences. The expected research outcomes will increase Australia’s international research standing in this burgeoning area of lipid-mediated T cell immunity.

该项目涉及发现微生物群产生的在T细胞介导的免疫中发挥重要作用的新的脂类。该项目结合了质谱学、蛋白质结晶学、免疫学和生物物理学等尖端技术，将阐明控制已识别的脂质和T细胞之间相互作用的分子因素。这一创新研究将在分子水平上为T细胞识别脂质的机制提供基础性的见解，从而拓宽我们在生物科学领域的知识。预期的研究结果将提高澳大利亚在这一新兴领域脂质介导的T细胞免疫领域的国际研究地位。