Molecular insights into the allosteric regulation of opioid receptors

阿片受体变构调节的分子见解

• 批准号: DE240100931
• 负责人: Dr Arisbel Batista Gondin
• 金额: $ 31.39万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE240100931
• 关键词: Molecular; insights; into; allosteric; regulation

Allosteric regulation is the biological process by which molecules bind to proteins someplace other than their active site, regulating their activity. Proteins on the cell surface called membrane receptors can be allosterically regulated to fine-tune the response of cells to the environment. This project aims to investigate how small molecules regulate receptor activity at a molecular level, using opioid receptors as an exemplar system. I will use an interdisciplinary approach that combines structural biology, medicinal chemistry, analytical pharmacology, and cell biology. The knowledge gained from these studies will advance fundamental understanding of receptor function and can lay the foundation for future drug discovery efforts.

变构调节是一种生物学过程，通过这种过程，分子与蛋白质的活性位点以外的其他地方结合，从而调节蛋白质的活性。细胞表面的蛋白质称为膜受体，可以通过变构调节来微调细胞对环境的反应。该项目旨在研究小分子如何在分子水平上调节受体活性，使用阿片受体作为范例系统。我将使用跨学科的方法，结合结构生物学，药物化学，分析药理学和细胞生物学。从这些研究中获得的知识将促进对受体功能的基本理解，并为未来的药物发现工作奠定基础。