The Development, Characterization, and Utilization of Radical Anion Clock Reactions

有机动力学项目将资助弗吉尼亚理工学院Tanko教授的研究，以开发一种明确而简单的实验方法，用于评估亲核试剂与羰基反应的单电子转移（SET）途径的重要性。将构建经过单电子还原的快速不可逆重排的特定底物，并将其用作自由基阴离子时钟，以测量在选定的一组有机反应中与SET相关的事件的时间行为。这项研究的意义在于它解决了有机化合物反应性的基本问题，并将更好地理解如何在合成有机方法中利用自由基阴离子。这项研究将设计和使用某些碳化合物，其结构使其表现为一种内部分子钟，可以在某些有机化合物反应时监测电子在分子水平上的行为方式。在分子水平上增加对事件发生时间的了解，将对具有重要商业意义的新药和化学品的生产产生重要影响

The Organic Dynamics program will fund the research of Professor Tanko at Virginia Polytechnic Institute to develop an unambiguous and simple experimental method which can be used to assess the importance of single electron transfer (SET) pathways in which nucleophiles react with carbonyl groups. Specific substrates which undergo rapid irreversible rearrangement upon one-electron reduction will be constructed and used as radical anion clocks to measure the temporal behavior of events associated with SET in a selected group of organic reactions. The significance of this research is that it addresses fundamental issues of the reactivity of oganic compounds and will lead to a better understanding of how radical anions can be exploited in synthetic organic methodology. This research will design and use certain carbon compounds whose architecture causes them to behave as a type of internal molecular clock which can monitor the way electrons behave at the molecular level when certain organic compounds react. Increased understanding about the timing of events at the molecular level will have important consequences for the production of new drugs and chemicals of commercial importance