Structurally Diverse Molecular Architectures with Unusual Excited State Dynamics and Reactivity Providing Multifunctional Interactions with DNA

结构多样的分子结构，具有异常的激发态动力学和反应性，提供与 DNA 的多功能相互作用

• 批准号: 1301131
• 负责人: James Tanko
• 金额: $ 36.25万
• 依托单位: Virginia Polytechnic Institute and State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1301131&HistoricalAwards=false
• 关键词: Structurally; Diverse; Molecular; Architectures; Unusual

The interaction of inorganic complexes, e.g., cis-platin, with DNA constitutes a major entry point into modulating the reactivity and molecular biology of this critical biomolecule. In this project funded by the Chemical Structure, Dynamics and Mechanism Program, Prof. Karen Brewer will design, prepare and study a group of structurally diverse inorganic complexes which undergo multiple reaction pathways with DNA, using a large array of sensitive methods. A series of new structural motifs with multifunctional reactivity will be prepared to expand the structural diversity of known molecules and create a large class of supermolecules for which each sub-unit modulates some property or performs some function that leads to molecular machines with very complex functions. Understanding and controlling the role of each sub-unit on the properties and reactivity of these unusual multifunctional molecules will be undertaken, including unusual systems that are excited with low energy red light. The project will explore the multifaceted reactivity of these systems including thermal binding to DNA, visible light-induced DNA photobinding via new mechanisms, red light activated DNA photocleavage, and a new paradigm for DNA modification, DNA photocondensation.The discovery of new materials which modulate the activity of DNA has many applications in medicine, including the treatment of genetic and infectious diseases. In addition, the knowledge base assembled by the development of such complex molecules with multiple reaction pathways is applicable in many fields, including the modification and detection of biomolecules, molecular sensing, light and redox activated molecular electronics, conversion of light energy to chemical energy and metal based catalysis.

无机复合物的相互作用，例如，顺铂与DNA构成调节这种关键生物分子的反应性和分子生物学的主要切入点。 在这个由化学结构，动力学和机制计划资助的项目中，Karen Brewer教授将设计，制备和研究一组结构多样的无机复合物，这些复合物使用大量敏感的方法与DNA进行多种反应途径。 将准备一系列具有多功能反应性的新结构基序，以扩大已知分子的结构多样性，并创造一大类超分子，其中每个亚单元调节某些性质或执行某些功能，从而导致具有非常复杂功能的分子机器。了解和控制每个亚单位对这些不寻常的多功能分子的性质和反应性的作用，包括用低能量红光激发的不寻常的系统。 该项目将探索这些系统的多方面反应性，包括与DNA的热结合、通过新机制的可见光诱导的DNA光结合、红光激活的DNA光切割以及DNA修饰的新范例DNA光凝聚。发现调节DNA活性的新材料在医学上有许多应用，包括治疗遗传和传染病。 此外，通过开发具有多个反应途径的这种复杂分子而组装的知识库可应用于许多领域，包括生物分子的修饰和检测、分子传感、光和氧化还原激活的分子电子学、光能到化学能的转换以及基于金属的催化。