Sampling fo Complex Materials for Mass Spectrometric Investigation

来自学术研究基础设施计划的这一奖项将帮助特拉华州大学化学系获得FT质谱仪和高功率激光系统，用于研究。 支持的研究活动包括：（1）气相金属卟啉化学研究，（2）多肽的激光解吸/电离和分子束研究，（3）分析高分子量材料，特别是生物分子的方法开发，以及（4）涉及高分子量、多功能或其他复杂材料的光处理研究。 质谱（MS）是一种用于探测紧密结构细节并获得大量有机、生物有机和有机金属分子的分子组成的技术。 电喷雾技术的加入将质谱的范围扩展到蛋白质和核酸分子量，远远超过任何其他技术。 电喷雾电离与高分辨率结合使用提供了质谱分析中可用的最新技术。 它为化学家提供了表征化合物的最强大的工具之一。 在质谱分析中获得这种能力对于许多化学领域的前沿研究至关重要。 可调谐激光器可以提供有关化学反应性的重要信息。 它的使用可能使我们在分子的反应性和非反应性的性质的理解上取得突破。

This award from the Academic Research Infrastructure Program will help the Department of Chemistry at the University of Delaware acquire a FT-Mass spectrometer and a high-powered laser system which will be used in research. The research activity to be supported includes (1) studies of gas phase metalloporphyrin chemistry, (2) laser desorption/ionization and molecular beam studies of polypeptides, (3) method development for analyzing high molecular weight material, particularly biological molecules, and (4) studies of photo- processes involving high molecular weight, polyfunctional or otherwise complex material. Mass Spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic and organometallic molecules. The addition of the technique of electrospray extends the range of MS to protein and nucleic acid molecular weights far beyond any other technique. The use of electrospray ionization in combination with high resolution provides the latest techniques available in mass spectrometry. It affords the chemist one of the most powerful tools available for the characterization of compounds. The acquisition of this capability in mass spectrometry is essential for the prosecution of frontier research in many fields of chemistry. A tunable laser can provide important information about chemical reactivity. Its use may enable breakthroughs in our understanding of the properties of reactive and nonreactive of molecules.