NCS-FO: Characterization and Decoding of Cortical Oscillatory Dynamics of Complex Hand Function
NCS-FO:复杂手部功能的皮质振荡动力学的表征和解码
基本信息
- 批准号:2124705
- 负责人:
- 金额:$ 98.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-01 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
In daily life, people grasp and hold an object with their hands, such as a hammer or an egg, frequently and dexterously. These tasks require different levels of steady grasp force and exert different sensations on the fingers and palm. This raises questions of how the brain regulates sustained grasp force and processes sensory input from different parts of the hand. This project will investigate cortical oscillations using high-density electrode grids while human subjects perform sustained hand grasp tasks and feel tactile stimuli such as touch and vibration. Novel computational algorithms will be developed and applied to the neural data to predict the produced grasp force and differentiate tactile inputs to the hand. This project will provide novel knowledge regarding the organization of sensorimotor cortex activity in relation to grasp force and tactile sensations. Brain regions that show unique activity in response to touch and vibration will then be stimulated with electrical pulses to elicit artificial sensations. Insights gained from this project will play a critical role in the development of closed-loop neuroprosthetics that can replicate natural hand function.Despite considerable progress regarding our understanding of the neural bases of sensorimotor behavior, there is very limited knowledge about the neural dynamics of sensory and motor cortical circuits during the generation of sustained complex hand function, such as grasping and tactile exploration, which are essential for common daily activities. A better understanding of the spatio-temporal neural dynamics associated with sustained complex hand movements and somatosensory processing is a necessary requirement for the construction of more efficient closed-loop neuroprosthetics. Utilizing advanced electrode technology, this project will record cortical activity with high-density electrocorticography (ECoG) grids, then decode multichannel data with computational intelligence for the identification of oscillatory patterns of the sensorimotor cortex during the execution of sustained hand grasp function. The high-density ECoG grids will provide recordings of brain activity across a large cortical space and with sub-centimeter resolution. Simultaneously, tactile sensory inputs--such as vibration and touch--will be delivered to different fingers and palm. The project will examine to what extent the cortical oscillations can be used to predict the produced grasp force and distinguish between different prolonged somatosensory inputs to the hand. The project will also develop a real-time system for the mapping cortical activations online, then stimulate cortical regions using channel suites and temporal patterns mimicking the ECoG modulations using a computer-in-the-loop system. The project will integrate neuroscience, neurosurgery and biomedical engineering expertise, to uncover spatio-spectral dynamics of somatosensory and motor cortical oscillations, and decode these patterns for the control of closed-loop hand neuroprosthetics. Outcomes will enable the design and development of neuroprosthetics more akin to the natural function of the hand.This project is funded by Integrative Strategies for Understanding Neural and Cognitive Systems (NCS), a multidisciplinary program jointly supported by the Directorates for Biology (BIO), Computer and Information Science and Engineering (CISE), Education and Human Resources (EHR), Engineering (ENG), and Social, Behavioral, and Economic Sciences (SBE).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
在日常生活中,人们经常灵巧地用手抓住一个物体,如锤子或鸡蛋。这些任务需要不同水平的稳定抓握力,并在手指和手掌上施加不同的感觉。这就提出了一个问题,即大脑如何调节持续的抓握力并处理来自手的不同部位的感觉输入。本项目将研究使用高密度电极网格的皮层振荡,而人类受试者执行持续的手抓任务和感觉触觉刺激,如触摸和振动。将开发新的计算算法并应用于神经数据,以预测所产生的抓握力并区分手部的触觉输入。这个项目将提供新的知识,关于组织的感觉运动皮层活动有关的把握力和触觉。对触摸和振动有独特反应的大脑区域将被电脉冲刺激,以引起人工感觉。从这个项目中获得的见解将在开发能够复制自然手功能的闭环神经假肢中发挥关键作用。尽管我们对感觉运动行为的神经基础的理解取得了相当大的进展,但在产生持续复杂的手功能(如抓握和触觉探索)期间,对感觉和运动皮层回路的神经动力学的了解非常有限,这是日常活动所必需的。更好地了解与持续复杂的手部运动和体感处理相关的时空神经动力学是构建更有效的闭环神经假肢的必要要求。利用先进的电极技术,该项目将记录皮层活动与高密度皮层电图(ECoG)网格,然后解码多通道数据与计算智能识别的振荡模式的感觉运动皮层在执行持续的手抓功能。高密度的ECoG网格将提供大脑活动的记录,跨越一个大的皮层空间和亚厘米分辨率。与此同时,触觉感官输入--如振动和触摸--将被传递到不同的手指和手掌。该项目将研究皮层振荡在多大程度上可以用来预测产生的抓握力,并区分不同的延长体感输入的手。该项目还将开发一个实时系统,用于在线映射皮层激活,然后使用通道套件和时间模式刺激皮层区域,模拟使用计算机在环系统的ECoG调制。该项目将整合神经科学,神经外科和生物医学工程专业知识,揭示体感和运动皮层振荡的空间光谱动力学,并解码这些模式以控制闭环手部神经假肢。该项目由理解神经和认知系统的综合策略(NCS)资助,这是一个由生物学(BIO),计算机和信息科学与工程(CISE),教育和人力资源(EHR),工程(ENG)和社会,行为,该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Long-latency gamma modulation after median nerve stimulation delineates the central sulcus and contrasts the states of consciousness
- DOI:10.1016/j.clinph.2022.10.008
- 发表时间:2022-11-10
- 期刊:
- 影响因子:4.7
- 作者:Asman,Priscella;Pellizzer,Giuseppe;Ince,Nuri F.
- 通讯作者:Ince,Nuri F.
Real-Time Delineation of the Central Sulcus with the Spatial Profile of SSEPs Captured with High-Density Ecog Grid
利用高密度 Ecog 网格捕获的 SSEP 空间轮廓实时描绘中央沟
- DOI:10.1109/embc48229.2022.9871900
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Asman, Priscella;Prabhu, Sujit;Tummala, Sudhakar;Ince, Nuri F.
- 通讯作者:Ince, Nuri F.
Microcontroller-Based Low Latency Audio System to Study Cortical Auditory Evoked Potentials: Applications with Intraoperative Language Mapping
基于微控制器的低延迟音频系统研究皮质听觉诱发电位:术中语言映射的应用
- DOI:10.1109/ner52421.2023.10123904
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Tasnim, Israt;Asman, Priscella;Swamy, Chandra Prakash;Tummala, Sudhakar;Prabhu, Sujit;Ince, Nuri Firat
- 通讯作者:Ince, Nuri Firat
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Nuri Ince其他文献
Feasibility of Stereo EEG Based Brain Computer Interfacing in An Adult and Pediatric Cohort
基于立体脑电图的脑机接口在成人和儿童群体中的可行性
- DOI:
10.1101/2024.06.12.598257 - 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Michael A. Jensen;Gerwin Schalk;Nuri Ince;Dora Hermes;Peter Brunner;Kai J Miller - 通讯作者:
Kai J Miller
Identification of candidate neural biomarkers of obsessive-compulsive symptom intensity and response to deep brain stimulation
- DOI:
10.1016/j.brs.2023.01.180 - 发表时间:
2023-01-01 - 期刊:
- 影响因子:
- 作者:
Nicole Provenza;Chandra Swamy;Luciano Branco;Evan Dastin-van Rijn;Saurabh Hinduja;Michaela Alarie;Ayan Waite;Michelle Avendano-Ortega;Sarah McKay;Greg Vogt;Huy Dang;Raissa Mathura;Bradford Roarr;Jeff Herron;Eric Storch;Jeffrey Cohn;David Borton;Nuri Ince;Wayne Goodman;Sameer Sheth - 通讯作者:
Sameer Sheth
Short-term anterior thalamic stimulation renders pattern-specific effects on limbic-network evoked cortical responses in drug-resistant epilepsy patients
短期丘脑前核刺激对耐药性癫痫患者边缘网络诱发皮质反应产生特定模式的影响
- DOI:
10.1016/j.brs.2024.12.652 - 发表时间:
2025-01-01 - 期刊:
- 影响因子:8.400
- 作者:
Teryn Johnson;Bobby Mohan;Christopher Harris;Amir Mbonde;Justin Cramer;Joseph Drazkowski;Amy Crepeau;Cornelia Drees;Matthew Hoerth;Katherine Noe;Nuri Ince;Nicholas Gregg;Gregory Worrell;Kai Miller;Dora Hermes;Jonathon Parker - 通讯作者:
Jonathon Parker
Chronic Ecological Assessment of Intracranial Neural Activity Synchronized to Disease-Relevant Behaviors in Obsessive-Compulsive Disorder
- DOI:
10.1016/j.biopsych.2023.02.041 - 发表时间:
2023-05-01 - 期刊:
- 影响因子:
- 作者:
Nicole Provenza;Evan Dastin-van Rijn;Chandra Prakash Swamy;Huy Dang;Sameer Rajesh;Nabeel Diab;Laszlo Jeni;Saurabh Hinduja;Michelle Avendano-Ortega;Sarah A. Mckay;Gregory S. Vogt;Bradford Roarr;Andrew Wiese;Ben Shofty;Jeffrey Herron;Kelly Bijanki;Eric Storch;Jeffrey Cohn;Nuri Ince;David Borton - 通讯作者:
David Borton
Identification of Candidate Neural Biomarkers of Obsessive-Compulsive Symptom Intensity and Response to Deep Brain Stimulation
- DOI:
10.1016/j.biopsych.2023.02.174 - 发表时间:
2023-05-01 - 期刊:
- 影响因子:
- 作者:
Nicole Provenza;Evan Dastin-van Rijn;Chandra Prakash Swamy;Luciano Branco;Saurabh Hinduja;Michelle Avendano-Ortega;Sarah A. Mckay;Gregory S. Vogt;Huy Dang;Bradford Roarr;Andrew Wiese;Ben Shofty;Jeffrey Herron;Matthew Harrison;Kelly Bijanki;Eric Storch;Jeffrey Cohn;Nuri Ince;David Borton;Wayne Goodman - 通讯作者:
Wayne Goodman
Nuri Ince的其他文献
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{{ truncateString('Nuri Ince', 18)}}的其他基金
Neuro-Marker Discovery for Accurate Localization of the Sub-Thalamic Nucleus for Deep Brain Stimulation
神经标记物发现,用于精确定位丘脑下核以进行深部脑刺激
- 批准号:
1343548 - 财政年份:2013
- 资助金额:
$ 98.35万 - 项目类别:
Standard Grant
Neuro-Marker Discovery for Accurate Localization of the Sub-Thalamic Nucleus for Deep Brain Stimulation
神经标记物发现,用于精确定位丘脑下核以进行深部脑刺激
- 批准号:
1067488 - 财政年份:2011
- 资助金额:
$ 98.35万 - 项目类别:
Standard Grant
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2319406 - 财政年份:2023
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2319451 - 财政年份:2023
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NCS-FO: Understanding the computations the brain performs during choice
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- 批准号:
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