Manipulating Intracellular Electron Carriers to Accelerate Microbial Detoxification Requiring Monooxygenation Reactions

操纵细胞内电子载体加速需要单氧合反应的微生物解毒

• 批准号: 9413824
• 负责人: Bruce Rittmann
• 金额: $ 25.34万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-04-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9413824&HistoricalAwards=false
• 关键词: Manipulating; Intracellular; Electron; Carriers; Accelerate

9413824 Rittmann This is a grant to support research the objective of which is to determine conditions under which monooxygenation reactions of secondary substrates can be accelerated while achieving other process goals in stable, suspended growth biological reactors that are used to treat contaminated wastewaters, leachates from landfills and groundwaters contaminated by chlorinated aliphatic and aromatic organic substances. The specific substrates the investigator plans on studying in this project are 4-chlorophenol and 2,4 dinitrophenol. A two stage process will be used in which the first reactor will be used to enrich the cells with the reduced electron-carrier and the second stage used to ensure removal of substances capable of biochemically exerting a demand for oxygen, to control growth of biomass and to provide adequate retention time for the biologically active solids. Aromatic hydrocarbons of petroleum origin, chlorinated aliphatic solvents and the nitroaromatics are the most commonly detected organic contaminants of water in the United States. Biological degradation of these compounds is an especially promising approach because, if successful, degradation is complete and likely to be economically viable under conditions that are not extreme regarding the physical conditions under which degradation takes place. Results of this project are expected to improve the design of biological reactors as they are used in environmental engineering practice. ***

9413824 Rittmann这是一笔赠款，以支持研究的目标是确定条件下，可以加速次级底物的单氧化反应，同时实现稳定的其他过程目标，悬浮生长生物反应器，用于处理受污染的废水，垃圾填埋场的沥滤液和被氯化脂肪族和芳香族有机物质污染的地下水。 本项目研究的具体底物为4-氯苯酚和2，4-二硝基苯酚。 将使用两阶段方法，其中第一反应器将用于用还原的电子载体富集细胞，第二阶段用于确保去除能够生物化学地施加对氧的需求的物质，以控制生物质的生长并为生物活性固体提供足够的保留时间。 石油来源的芳烃、氯化脂肪族溶剂和硝基芳烃是美国最常检测到的水中有机污染物。 这些化合物的生物降解是一种特别有前途的方法，因为如果成功，降解是完全的，并且在发生降解的物理条件方面不是极端的条件下可能是经济上可行的。 该项目的结果有望改善生物反应器的设计，因为它们被用于环境工程实践。 ***