Acquisition of Instrumentation for the Establishment of a Center for Molecular Structure in the California State University

采购仪器用于在加州州立大学建立分子结构中心

• 批准号: 9413955
• 负责人: Katherine Kantardjieff
• 金额: $ 29.66万
• 依托单位: CSU Fullerton Auxiliary Services Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9413955&HistoricalAwards=false
• 关键词: Acquisition; Instrumentation; Establishment; Center; Molecular

The Department of Chemistry and Biochemistry at California State University, Fullerton (CSUF), is embarking on a major new initiative to develop a Center for Molecular Structure which will serve the largest four-year and Masters' degree- granting public university system (CSU) in the United States. We have recently been designated as the site for a core facility for research and training in this area by the California State University Program for Education and Research in Biotechnology (CSUPERB). Our campus, the University system and industry enthusiastically support this project and have committed well over 50% of the costs of developing this core facility. The x-ray laboratory of the Center will be housed in renovated facilities specifically designed for this Center, to be located in McCarthy Hall adjacent to our new 60,000 square foot Science Laboratory Center (SLC). Critical to the efficient and timely establishment of this core facility are NSF funds which we are requesting here to acquire a modern, high-powered crystallographic system and computer workstations for small molecule and macromolecular applications. The Siemens instrumentation we have selected is a completely integrated multiwire area detector/rotating anode crystallography system for macromolecules that can also be used as a small molecule diffractometer. The configuration of the Silicon Graphics workstations and software library, the first of its kind in the CSU system, is ideally suited to meeting the needs of our students and faculty in a variety of structural studies. These include 1 ) structural studies on bacterial toxins, bovine ceruloplasmin, horse spleen and serum ferritins, gly- and phe-tRNA synthetases from E. coli, and model complexes of heme proteins; 2) structural studies of novel organometallic compounds, di- and trinuclear platinum compounds, and lithium salts of dianions; 3) molecular modeling studies of hemoproteins and organotin-based polymer systems; 5) comput ational studies on oxyallyl cation chemistry; 6) lipid bilayer simulations. The Director of the Center is Dr. Katherine Kantardjieff, who joined the CSUF faculty in 1989 from the Molecular Biology Institute and Department of Chemistry at UCLA, where she worked in David Eisenberg's group studying the structure of diphtheria toxin. The Department of Chemistry and Biochemistry at CSUF is committed to high-quality research programs as an integral part of both our undergraduate and graduate education programs. The 20 full- time faculty in the Department have established an exemplary record of external funding and consistently publish in the top peer-reviewed journals in their field. This project, however, will advance not only the research and training capabilities of our Department, but also those of the entire 20 campus CSU system. Facilities within the Center will complement, not duplicate, existing NMR, EPR and electron microscope facilities at CSUF and within the CSU. Facilities within the Center will provide molecular modeling capabilities and computational power to the entire CSU by means of the existing high-speed fiber optic network. The Center for Molecular Structure will promote the advancement of knowledge at the mainstream of scientific endeavor and make a significant contribution to the training and development of the next generation of scientists.

加州州立大学富勒顿分校(CSUF)化学和生物化学系正在开展一项重大的新倡议，以建立一个分子结构中心，该中心将为美国最大的四年制和授予硕士学位的公立大学系统(CSU)提供服务。我们最近被加州州立大学生物技术教育和研究计划(CSUPERB)指定为这一领域研究和培训的核心设施的选址。我们的校园、大学系统和产业界都热情地支持这一项目，并承担了开发这一核心设施的50%以上的成本。该中心的X射线实验室将设在专门为该中心设计的翻新设施中，位于麦卡锡大厅，毗邻我们新的60,000平方英尺的科学实验室中心(SLC)。对于高效和及时地建立这一核心设施至关重要的是NSF资金，我们在这里请求这些资金来购买用于小分子和大分子应用的现代、高功率晶体系统和计算机工作站。我们选择的西门子仪器是一个完全集成的多线区域检测器/旋转阳极大分子结晶学系统，也可以用作小分子衍射仪。Silicon Graphics工作站和软件库的配置是CSU系统中的第一个此类配置，非常适合满足我们学生和教师在各种结构研究中的需求。这些研究包括：1)细菌毒素、牛铜蓝蛋白、马脾和血清铁蛋白、大肠杆菌Gly和Phe-tRNA合成酶的结构研究，以及血红素蛋白的模型化合物；2)新型有机金属化合物、双核和三核铂化合物以及二阴离子锂盐的结构研究；3)血红素蛋白和有机锡聚合物体系的分子模拟研究；5)氧烯丙基阳离子化学的计算研究；6)脂双层模拟。该中心的主任是凯瑟琳·坎塔吉夫博士，她于1989年从加州大学洛杉矶分校分子生物学研究所和化学系加入CSUF教员，在那里她在David Eisenberg的团队中研究白喉毒素的结构。CSUF化学和生物化学系致力于高质量的研究项目，作为我们本科和研究生教育项目的组成部分。该系的20名全职教员建立了外部资助的模范记录，并一直在其所在领域的顶级同行评议期刊上发表文章。然而，这个项目不仅将促进我们系的研究和培训能力，而且将促进整个20个校园CSU系统的研究和培训能力。该中心内的设施将补充而不是重复CSUF和CSU内现有的核磁共振、EPR和电子显微镜设施。该中心内的设施将通过现有的高速光纤网络向整个CSU提供分子建模能力和计算能力。分子结构中心将促进科学工作主流知识的进步，并为培养和发展下一代科学家做出重大贡献。