Acquisition of Instrumentation for the Establishment of a Center for Molecular Structure in the California State University

加州州立大学富勒顿分校（CSUF）化学与生物化学系正在着手一项重大的新计划，以建立一个分子结构中心，该中心将服务于美国最大的四年制和授予硕士学位的公立大学系统（CSU）。我们最近被加州州立大学生物技术教育和研究项目（CSUPERB）指定为该领域研究和培训的核心设施所在地。我们的校园，大学系统和行业热情支持这个项目，并承诺超过50%的开发这个核心设施的成本。该中心的x射线实验室将被安置在专门为该中心设计的翻新设施中，该设施将位于麦卡锡大厅，毗邻我们新的60,000平方英尺科学实验室中心（SLC）。有效和及时建立这个核心设施的关键是国家科学基金会的资金，我们在这里要求获得一个现代化的，高功率的晶体系统和用于小分子和大分子应用的计算机工作站。我们选择的西门子仪器是一个完全集成的多线区域检测器/旋转阳极晶体学系统，用于大分子，也可以用作小分子衍射仪。Silicon Graphics工作站和软件库的配置是科罗拉多州立大学系统中第一个此类配置，非常适合满足学生和教师在各种结构研究中的需求。这些研究包括：1)细菌毒素、牛铜蓝蛋白、马脾脏和血清铁蛋白、大肠杆菌gly-和phe-tRNA合成酶以及血红素蛋白模型复合物的结构研究；2)新型有机金属化合物、二核和三核铂化合物、锂离子盐的结构研究；3)血红蛋白和有机锡基聚合物体系的分子模拟研究；氧烯丙基阳离子化学的计算研究；6)脂质双分子层模拟。该中心的主任是Katherine kantardjeff博士，她于1989年从加州大学洛杉矶分校的分子生物学研究所和化学系加入CSUF，在那里她在David Eisenberg的小组中研究白喉毒素的结构。CSUF化学与生物化学系致力于高质量的研究项目，作为我们本科和研究生教育项目的一个组成部分。该系的20名全职教师已经建立了外部资助的典范记录，并始终在各自领域的顶级同行评审期刊上发表文章。然而，这个项目不仅将提高我们部门的研究和培训能力，而且将提高整个20个校区CSU系统的研究和培训能力。中心内的设施将补充而不是复制CSUF和CSU内现有的核磁共振、EPR和电子显微镜设施。该中心内的设施将通过现有的高速光纤网络为整个CSU提供分子建模能力和计算能力。分子结构研究中心将推动科学研究主流领域的知识进步，为培养和发展下一代科学家做出重要贡献。

The Department of Chemistry and Biochemistry at California State University, Fullerton (CSUF), is embarking on a major new initiative to develop a Center for Molecular Structure which will serve the largest four-year and Masters' degree- granting public university system (CSU) in the United States. We have recently been designated as the site for a core facility for research and training in this area by the California State University Program for Education and Research in Biotechnology (CSUPERB). Our campus, the University system and industry enthusiastically support this project and have committed well over 50% of the costs of developing this core facility. The x-ray laboratory of the Center will be housed in renovated facilities specifically designed for this Center, to be located in McCarthy Hall adjacent to our new 60,000 square foot Science Laboratory Center (SLC). Critical to the efficient and timely establishment of this core facility are NSF funds which we are requesting here to acquire a modern, high-powered crystallographic system and computer workstations for small molecule and macromolecular applications. The Siemens instrumentation we have selected is a completely integrated multiwire area detector/rotating anode crystallography system for macromolecules that can also be used as a small molecule diffractometer. The configuration of the Silicon Graphics workstations and software library, the first of its kind in the CSU system, is ideally suited to meeting the needs of our students and faculty in a variety of structural studies. These include 1 ) structural studies on bacterial toxins, bovine ceruloplasmin, horse spleen and serum ferritins, gly- and phe-tRNA synthetases from E. coli, and model complexes of heme proteins; 2) structural studies of novel organometallic compounds, di- and trinuclear platinum compounds, and lithium salts of dianions; 3) molecular modeling studies of hemoproteins and organotin-based polymer systems; 5) comput ational studies on oxyallyl cation chemistry; 6) lipid bilayer simulations. The Director of the Center is Dr. Katherine Kantardjieff, who joined the CSUF faculty in 1989 from the Molecular Biology Institute and Department of Chemistry at UCLA, where she worked in David Eisenberg's group studying the structure of diphtheria toxin. The Department of Chemistry and Biochemistry at CSUF is committed to high-quality research programs as an integral part of both our undergraduate and graduate education programs. The 20 full- time faculty in the Department have established an exemplary record of external funding and consistently publish in the top peer-reviewed journals in their field. This project, however, will advance not only the research and training capabilities of our Department, but also those of the entire 20 campus CSU system. Facilities within the Center will complement, not duplicate, existing NMR, EPR and electron microscope facilities at CSUF and within the CSU. Facilities within the Center will provide molecular modeling capabilities and computational power to the entire CSU by means of the existing high-speed fiber optic network. The Center for Molecular Structure will promote the advancement of knowledge at the mainstream of scientific endeavor and make a significant contribution to the training and development of the next generation of scientists.