Engineering Growth Factor/Receptor Processes

工程生长因子/受体过程

• 批准号: 9414115
• 负责人: Douglas Lauffenburger
• 金额: $ 14.28万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-15 至 1995-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9414115&HistoricalAwards=false
• 关键词: Engineering; Growth; Factor; Receptor; Processes

9414115 Lauffenburger This project is on research to better understand the dynamics of growth factors and their receptors, focusing on the epidermal growth factor system. The object of the work is to manipulate growth factor ligands as a means of altering trafficking. There are three specific aims for the period of study: (1) to manipulate parameters in receptor/ligand and receptor/cell interactions in order to test previously constructed models of receptor dynamics; (2) to investigate ligand transport through model tissues; and (3) to study model autocrine/paracrine regulatory systems created by inserting engineered ligands and regulatory elements into cell lines. The understanding of growth factor/receptor dynamics and trafficking could lead to improvements in wound healing, drug delivery, gene therapy, and tissue regeneration. ***

这个项目的研究是为了更好地了解生长因子及其受体的动态，重点是表皮生长因子系统。这项工作的目的是操纵生长因子配体作为改变贩运的手段。研究期间有三个具体目标：(1)操纵受体/配体和受体/细胞相互作用中的参数，以测试先前构建的受体动力学模型；(2)研究配体在模型组织中的转运；(3)研究通过将工程配体和调控元件插入细胞系而建立的自分泌/旁分泌调节系统模型。对生长因子/受体动力学和运输的理解可以改善伤口愈合、药物输送、基因治疗和组织再生。＊＊＊