Organic Reactions and Syntheses in Water Solution

水溶液中的有机反应与合成

• 批准号: 9414855
• 负责人: Ronald Breslow
• 金额: $ 51万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-01-01 至 1997-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9414855&HistoricalAwards=false
• 关键词: Organic; Reactions; Syntheses; Water; Solution

With funding from the Organic Dynamics Program Professor Breslow of Columbia University will develop methods that cause organic reactions to occur in water solutions. Organic molecules will be incorporated into cyclodextrin cavities and these complexes will be dissolved in aqueous solutions. This technique will allow the study of the effects of water on normally hydrophobic reactions of organic compounds. Cyclodextrins will be modified to contain by covalent bonds biphasic organic catalysts whose ability to accelerate certain organic reactions in the presence of metal ions will be studied. The use of selected cyclodextrins will also allow the determination of specific geometry requirements that are anticipated to occur in selected organic reactions. The goals described in the proposal are applicable to the area of environmentally chemically benign synthesis. This research will use the unique shapes of naturally occurring cyclodextrins, found in plants rich in starch, as miniature containers in which certain organic reactions will occur while the entire mixture is dissolved in water. Many organic substances resist interacting with water and exhibit hydrophobic behavior. The use of cyclodextrins as containers which dissolve in water will allow a unique study of the hydrophobic reactivity of organic compounds in a water environment. This research represents an important development of environmentally benign chemical synthesis studies that can help to reduce pollution from manufacturing processes in the chemical industry.

在有机动力学计划的资助下，哥伦比亚大学的Breslow教授将开发在水溶液中引起有机反应的方法。 将有机分子掺入环糊精空腔中，这些复合物将溶解在水溶液中。 这种技术将允许水对有机化合物的正常疏水反应的影响的研究。 环糊精将通过共价键进行改性，使其含有两相有机催化剂，研究其在金属离子存在下加速某些有机反应的能力。 使用选定的环糊精也将允许确定预期在选定的有机反应中发生的特定几何要求。 提案中所述的目标适用于环境化学良性合成领域。 这项研究将使用天然存在的环糊精的独特形状，在富含淀粉的植物中发现，作为微型容器，当整个混合物溶解在水中时，某些有机反应将发生。 许多有机物质抵抗与水的相互作用并表现出疏水性。 使用环糊精作为溶于水的容器将允许对有机化合物在水环境中的疏水反应性进行独特的研究。 这项研究代表了环境友好型化学合成研究的重要发展，有助于减少化学工业生产过程中的污染。