How is the blood cell population size controlled?

如何控制血细胞群的大小？

• 批准号: FT220100023
• 负责人: Dr Travis Johnson
• 金额: $ 54.61万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT220100023
• 关键词: How; blood; cell; population; size

Macrophage-like cells are an ancient animal blood cell lineage critically important for development, immunity, and homeostasis. This fellowship seeks to reveal the genes and control mechanisms used by animals to achieve an optimally-sized army of these cells - to contain threats for survival upon infection, heal following acute stress exposures, or for development, ongoing maintenance, and repair of wear and tear. By marrying the genetic tractability of the model organism Drosophila and its simple, yet conserved blood cell system, this project will yield new insights into the mechanisms that govern the animal blood cell population. This will benefit our fundamental understanding of how animals maximise their health throughout life.

巨噬细胞样细胞是一种古老的动物血细胞谱系，对发育、免疫和体内平衡至关重要。这项研究旨在揭示动物用于实现这些细胞的最佳规模军队的基因和控制机制-包含感染后生存的威胁，急性应激暴露后的愈合，或用于发育，持续维护和修复磨损。通过将模式生物果蝇的遗传可塑性与其简单而保守的血细胞系统相结合，该项目将对控制动物血细胞群体的机制产生新的见解。这将有助于我们从根本上理解动物如何在一生中最大限度地保持健康。