A novel mechanism for the control of growth factor activity

控制生长因子活性的新机制

• 批准号: DE150101648
• 负责人: Dr Travis Johnson
• 金额: $ 25.04万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE150101648
• 关键词: novel; mechanism; control; growth; factor

Growth factors are secreted signalling molecules that govern fundamental biological processes such as cell growth, proliferation and death. The mechanism for growth factor control by a Membrane Attack Complex/Perforin-like (MACPF) protein is highly novel as MACPF proteins typically function to kill pathogens during the vertebrate immune response. This project aims to reveal how the MACPF protein Torso-like controls highly localised growth factor signalling, using the sophisticated genetic and advanced imaging methods possible in the fruit fly Drosophila. This project aims to understand growth factor control as its deregulation leads to serious developmental disorders and diseases.

生长因子是分泌的信号分子，其控制基本生物过程，如细胞生长、增殖和死亡。由膜攻击复合物/穿孔蛋白样（MACPF）蛋白控制生长因子的机制是非常新颖的，因为MACPF蛋白通常在脊椎动物免疫应答期间起杀死病原体的作用。该项目旨在揭示MACPF蛋白Torso样如何控制高度局部化的生长因子信号传导，使用果蝇中可能的复杂遗传和先进成像方法。该项目旨在了解生长因子控制，因为其放松管制会导致严重的发育障碍和疾病。