U.S.-Australia Cooperative Research: Collagen Stability andInteractions

美国-澳大利亚合作研究：胶原蛋白稳定性和相互作用

• 批准号: 9418662
• 负责人: Barbara Brodsky
• 金额: $ 2.53万
• 依托单位: Rutgers, The State University of New Jersey-RBHS-Robert Wood
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-06-01 至 1998-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9418662&HistoricalAwards=false
• 关键词: U.S.; Australia; Cooperative; Research; Collagen

94118662 Brodsky This award will support travel expenses and communication costs, over a three year period, to enable Dr. Barbara Brodsky from the Department of Biochemistry at the Robert Wood Johnson Medical School in Piscataway, New Jersey, to conduct cooperative research with Dr. John A. M. Ramshaw of the CSIRO Department of Biomolecular Engineering in Parkville, Victoria, Australia. The work will focus on defining the role specific amino acids found in collagen have in the biological function of the protein. The collagen triple-helix is the main protein in all connective tissues, and collagen containing materials are becoming important as biomaterials, as well as in the more traditional leather and gelatin industries. The principal investigators are collaborating on a model peptide approach to determine the effect of specific sequences on triple-helix stability and dynamics, to identify the structural features of functional regions in collagen, and to design collagen-like peptides which can form ordered arrays. The interests, expertise and facilities available through this collaboration are complementary to the proposed project. The visit by Dr. Ramshaw to the laboratory in New Jersey is funded by the Australian Department of Industry, Science and Technology (DIST) under the U.S.-Australia Cooperative Science Program.

小行星94118662 该奖项将在三年内支持差旅费和通信费用，以使新泽西皮斯卡特维罗伯特伍德约翰逊医学院生物化学系的Barbara Brodsky博士能够开展合作 约翰·A博士的研究M. Ramshaw博士说。 这项工作将集中在定义胶原蛋白中发现的特定氨基酸在蛋白质生物学功能中的作用。 胶原蛋白三螺旋是所有结缔组织中的主要蛋白质，并且含胶原蛋白的材料作为生物材料以及在更传统的皮革和明胶工业中变得重要。 主要研究人员正在合作研究一种模型肽方法，以确定特定序列对三螺旋稳定性和动力学的影响，以确定胶原蛋白中功能区域的结构特征，并设计可以形成有序阵列的胶原蛋白样肽。 兴趣、专业知识和设施 通过这一合作提供的信息是对拟议项目的补充。 Ramshaw博士对位于新泽西的实验室的访问是由澳大利亚工业、科学和技术部（DIST）根据美国-澳大利亚合作科学计划。